Global ETD Search
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Showing 1 to 5 of 5 for “"ectopic calcification"”.
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Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
Ectopic calcification (EC) is a complex disease in which mineral develops in abnormal locations. It can develop in a variety of locations throughout the body, including the vasculature, heart valves, and in orthopedic settings where it is more commonly referred to as heterotopic ossification (HO). …
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Biochemische und funktionelle Charakterisierung einer gerichteten Gendeletion (Knockout) von Fetuin-A in Mäusen
… is regarded as the main reason for pathological calcification in arteries and soft tissues, as seen in chronic renal failure. However, recent studies show that proteins also low molecular weight compounds act as inhibitiors of unwanted mineral precipitation. The serum protein fetuin-A/a2-HS …
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Gene deletion and functional analysis of Fetuin-B
… phenotypes: fetuin-A deficiency leads to ectopic calcification, while fetuin-B deficiency leads to female infertility. The data provided by this study thus clearly suggests that the fetuin-family members have distinct functions in vivo.
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… remodeling of the extracellular matrix (ECM), ectopic calcification, and inflammation. Symptomatically, these are reflected peripherally in the dermis, retina, and vascular walls. Mutations in the ATP binding cassette subfamily C member 6 (ABCC6) gene are the cause of PXE. ABCC6 is primarily …
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Effect of the Pdgfbʳᵉᵗ mutation on cardiovascular homeostasis
… development of vascular associated brain calcification in 4–12-month-old pdgfbret/ret mice and alterations to left ventricular structure from 10 to 20 weeks of age. In this thesis, I have investigated the hypothesis that calcification develops throughout the vasculature in pdgfbret/ret …