Global ETD Search
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Showing 1 to 3 of 3 for “"eccDNA"”.
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DNA DAMAGE AT TANDEM REPEATS GENERATES I-LOOPS THAT CAN BE EXCISED AS ECCDNA
Extrachromosomal circular DNA (eccDNA) molecules are ubiquitous species found in normal tissues that accumulate in cancer cells. Though affecting several cellular functions, the exact molecular steps enabling their genesis remain elusive. We have recently discovered internal loop structures …
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Non-Parametric Analyses of the Regulatory Roles of LINE-1 Retrotransposons during Motor Neuron Differentiation
… L1-derived extrachromosomal circular DNAs (eccDNAs) from Circulome-seq datasets. I characterized differential eccDNA compositions in ESC and MN cell types and found differential enrichment of transcription factor binding motifs in cell type specific eccDNAs. Third, I present inferential …
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Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae
Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae Ryan Matthew Hull Repetitive regions of the genome, such as the centromeres, telomeres and ribosomal DNA account for a large proportion of the genetic variation between individuals. Differences in the number …