Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ecDNA"”.
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
… material was termed extrachromosomal DNA (ecDNA). ecDNA appears to be epigenetically highly accessible and transcriptionally active compared with chromosomal DNA, which may partially underlie their critical roles in driving oncogene overexpression and cancer evolution. However, the full …
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A Neural Network and Genome Language Model Based Approach to Understanding DNA Replication in Cancer
… DNA Recently, the role of extrachromosomal DNA (ecDNA) in cancer has gained a lot of attention because ecDNA often harbours oncogene amplifications, driving rapid tumour evolution, and occurs in ~17 % of all newly diagnosed cancers. I used DNAscent to study the DNA replication dynamics on ecDNA …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… with complex SVs such as extrachromosomal DNA (ecDNA) and chromothripsis. We discovered underappreciated features of ecDNAs in GBM, including a high prevalence of ecDNAs generated via episomal exclusion, and uncovered the extent by which ecDNAs shape tumoural heterogeneity via seismic …