Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ebolavirus"”.
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Sphingomyelinases and Lysosomal Trafficking in Ebolavirus Entry
Ebolavirus (EBOV) is a negative sensed, single-strand filovirus which causes up to 90% mortality. Despite increasing outbreaks over the past decade, no approved vaccines or therapies exist. One drug treatment strategy is to target virus entry mechanisms. EBOV enters the cell using a …
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Developing VHH-based tools to study Ebolavirus infection
… tools to study infectious disease, specifically Ebolavirus entry. In Chapter 1, I provide an overview about antibodies and how antibodies have transformed the biomedical field and how single domain antibody fragments, or VHHs, have entered this arena. I will also touch upon how VHHs have been …
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Antibody-based diagnostics and therapeutics for Zaire ebolavirus and Burkholderia pseudomallei
Zaire ebolavirus (EBOV) and Burkholderia pseudomallei are the causative agents of Ebola virus disease (EVD) and melioidosis, respectively. Early diagnosis is critical for halting the spread of the disease or providing treatment of the disease. Current diagnosis for EBOV includes polymerase chain …
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A Point-of-Care Immunoassay for Ultra-Sensitive Detection of Ebolavirus
… pair that targets non-overlapping epitopes of ebolavirus secreted glycoprotein, a truncated version of the structural glycoprotein that is actively secreted from infected cells in early stages of the infection. The generation of these antibodies was achieved by associating scFv phage-display …
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Mapping the Major Epitope(s) of the Glycoprotein of Ebolavirus with QB Phage Display System
… phages harboring gene segments of the Ebolavirus glycoprotein fused to the Qβ phages A1 coat protein. All the phages with the glycoprotein determinants will be analyzed for their antigenicity using specific glycoprotein antibody once they are available. Additionally, our panning …
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Bundibugyo Versus Zaire Ebolaviruses: Examination of the Polymerase Complex as a Therapeutic Target
Ebolaviruses, of the family Filoviridae, are the causative agents of outbreaks of hemorrhagic fever throughout Africa. In eastern Africa, three outbreak causing species of ebolavirus overlap in geographic distribution: Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV), and Bundibugyo ebolavirus …
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Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
… LPS as well as non-LPS ligands such as the Zaire ebolavirus glycoprotein. Key regulators in the TLR4 pathway are RIPK1 and RIPK3, which are essential during programmed cell death, and therefore, signalling via TLR4 is key in the decision between pro immunity or cell death during infection. Whilst …
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
Sudan Ebola (SUDV), Marburg (MARV), and Lassa fever (LASV) viruses cause acute, severe haemorrhagic fevers resulting in high morbidity and mortality in overlapping regions of Africa. Despite millions of individuals in Africa being at risk of contracting an infection from one of these viruses, …