Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"early-life adversity"”.
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The impact of early life adversity on later life health
<p>The preponderance of the literature on early life adversity suggests that adversity has negative effects on later life health; however, an emerging body of literature suggests that early life adversity may develop a sense of resilience in individuals. Drawing from life course perspective, the …
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The nature, structure, and neural signature of early life adversity
… salient environmental influence is that of adversity experienced in early life. The long-term consequences of such experiences on cognitive development and mental health outcomes are well-documented. However, there remain gaps in understanding the precise neuropsychological pathways through …
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The Impact of Early Life Adversity on Mediodorsal Thalamic-Prefrontal Cortex Maturation
Exposure to early life adversity (ELA) is known to disturb neural development and interfere with neural circuit function, causing long-lasting adverse effects on cognitive and affective behaviors. The basis for this is thought to be linked to developmental disruption of neural circuits underpinning …
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The Impact of Early Life Adversity on Neural Reward Reactivity in Early Childhood
Early Life Adversity (ELA), defined as childhood experiences which require significant adaptation beyond the child’s developmental stage, is of critical concern, as it is predictive of increased risk for the leading causes of morbidity and increased severity, chronicity, and overall risk for …
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Contributions of early life adversity, sex, and traits towards compulsive opioid self-administration
… evidence suggests that individual differences in early life experience, biological sex, personality traits, and neurobiology of the reward system are all associated with the development of addiction. A dimensional model of how all these factors relate to addiction is necessary, but simultaneously …
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
<p>Early life adversity (ELA) is the exposure to a single or to multiple traumatic events before the age of 18 that go beyond the child’s coping. These adverse events are often exacerbated during adolescence particularly when cognitive performance is compromised. Adolescents who experienced ELA may …
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How the Outside Gets in: Linking Social and Physical Environments with Physiology and Body Size in Wild Baboons
… two environmental factors – dominance rank and early-life conditions – are associated with growth and physiology. My colleagues and I test these links in a population of wild baboons studied by the Amboseli Baboon Research Project. The Amboseli Baboons Research Project has been collecting …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
Early life adversity has profound health implications in later life. Individuals that experience early life adversity as neonates in the form of preterm birth, or those that require surgical intervention later, exhibit altered pain sensitivity. Fragmented maternal care (FC) is potentially the most …
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A Qualitative Exploration Of Trauma, Familismo, And Resilience In Three Mexican Immigrant Families.
… revealed three central themes: childhood adversity, familismo (commitment to family), and resilience. While the data did not explicitly demonstrate trauma transmission, the findings revealed the lasting impact of early life adversity on family members. Familismo emerged as a significant …
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“Anything I do now feels like an act of resilience”: adversity, resilience, and wellbeing in female survivors of domestic abuse
… sought to explore the under-researched areas of adversity, resilience, and wellbeing in female survivors of Domestic Abuse (DA). We employed a multi-phase mixed-methods research design comprising a cross-sectional online quantitative survey in phase one and qualitative remote interviews in phase …
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Epigenetic & transcriptomic alterations associated with childhood maltreatment, major depressive disorder, and post-traumatic stress disorder
… post-traumatic stress disorder (PTSD) later in life. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a regulator of the body’s stress response, has been associated with exposure to childhood maltreatment, MDD, and PTSD. Additional work has shown that a history of childhood …
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Developmental burden of childhood adversity: Insight from longitudinal perspectives
Childhood adversity has been implicated in poorer developmental outcomes such as behavioral problems, poorer mental health and cognitive deficits. Studies have also linked adversity to alterations in cortical brain structures. To date however, almost all knowledge of the effects of adversity on …
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Friends or foes? Blood parasite costs and defence abilities in young raptor hosts
Short after coming to life, young vertebrates face many new challenges. How early-life adversity is dealt with during this critical developmental period primes a spectrum of long-term consequences for host fitness, that may ultimately regulate population dynamics. In this thesis, I intend to …
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Oxytocin and Social Sensitivity: Implications for Vulnerability to Stress and Depressive Symptoms
… receptor gene (OXTR) moderated the influence of early-life events in relation to later depressive symptoms. In the absence of this polymorphism individuals who experienced early-life maltreatment displayed high levels of depressive symptoms, but this was not evident in the presence of this …
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Understanding the Complex Mental Health Challenges of Children and Adolescents Seeking Community-based Care
… the paths from internalizing challenges, early life adversity, and sex were only significant among the ND group, indicating that neurodevelopmental status is an important moderator of outcomes. In Study 2, a mixed methods approach was employed to examine how neuropsychological information …
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Understanding the Role of Pubertal Timing and Tempo with Adolescent Brain Development: Effects of Childhood Maltreatment and Mental Health Outcomes in Young Adulthood
… models of stress acceleration propose that early life adversity may be associated with accelerated biological aging, including faster neurodevelopment, earlier pubertal timing, and faster pubertal development. The current study aimed to clarify longitudinal pathways from childhood abuse and …
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
… a possible treatment for disturbances caused by early exposure to ethanol and investigates the effects of additional early-life stress in animal models of FASD. The first study, using a third-trimester equivalent animal model of FASD (4 g/kg/day i.p., 12 % v/v, P4 - P9), investigated …
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Psychological and Biological Sequelae of Exposure to Prenatal Maternal Depression: Findings from the 25-Year Prospective South London Child Development Study
… compared to non-exposed offspring. No effect of early life adversity on metabolic function was observed. <br/>Conclusions: Exposure to prenatal maternal depression results in persistent psychological and biological changes in the offspring that are observable during young adulthood. Childhood …
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A cross-species network science approach to childhood adversity
… organ whose development is responsive to its early-life environment. This means that early experiences shape the biological substrates of lifelong health and well-being. Indeed, exposure to significant adversity in childhood increases the risk of a range of cognitive and behavioural …
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