Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"early-endosome"”.
-
Vps1's Role From the Early Endosome to the Golgi
… protein trafficking from the late Golgi-to-endosome, peroxisome fission, vacuole fission and fusion, and retention of Golgi proteins. We recently observed in FM4-64 pulse-chase experiment with vps1 null cells that the levels of accumulated FM4-64-carrying transport vesicles increased …
-
Vps1, a Novel Recycling Factor For the Traffic of Early Endosome to Late Golgi
… budding yeast, there are recycling traffics from early and late endosomal compartments to the late Golgi. Here, I examined a possible role for Vps1, a large GTPase, in the recycling traffic of GFP-Snc1 from early endosomes to the late Golgi. In the absence of Vps1, I observed an aberrant …
-
Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes
… in the endocytic pathway, in particular, early endosome processing and delivery to the lysosomes. Two models for endosome processing have previously been proposed in the literature, namely the maturation and vesicular traffic models. The general consensus has been an early phase of …
-
The interrelationship between the endosomal sorting regulators RAB21, Retromer and WASH complex
… sorting occurs in the endosomal network. The early endosome is the first step in the sorting process. The early endosome recruits several sorting complexes namely retromer, commander and WASH complex to facilitate the proper trafficking of cargo. The sorting complexes such as WASH and retromer …
-
Investigations into the Nature of the Endosomal System in Plasmodium falciparum
… well-conserved protein components of the late endosome, the retromer cargo-selective complex and Rab7, were found on a previously un-described inherited structure adjacent to the parasite Golgi apparatus and in close opposition to nascent rhoptries (specialized secretory organelles required for …
-
The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… triplication of human chromosome 21. By age 40, nearly all individuals with DS develop amyloid beta (Aβ) plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer’s disease (AD). This increased susceptibility to Alzheimer’s Disease in Down syndrome (AD-DS) has primarily been …
-
Regulation of hepatocyte growth factor receptor endocytic trafficking
… of internalization or during sorting at the early endosome for degradation, leads to oncogenic activation of HGFR. Impaired HGFR trafficking is emerging as a key mechanism for HGFR-induced cancer progression and metastasis. \r\nA major goal of my dissertation was to lay the foundation for …
-
Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… receptor internalization into early endosomes. Here internalized receptors are\r\nsorted for degradation in lysosomes, direct recycling back to the cell surface or indirect\r\nrecycling via a second recycling compartment called the pericentriolar recycling\r\nendosome. Rab …
-
A novel mechanism for the anti-cancer activity of aspirin and its analogues
… also driving EGF co-localization with early-endosome antigen-1 (EEA1). The perturbation of the internalization of EGF by aspirin and PN517 was also observed by a time-lapse assay using live confocal imaging. These compounds also had specific effects on different tyrosine phosphorylation …
-
Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
… the demand for these is higher than ever. Clearly, rational development of new profylactic and therapeutic strategies is needed to tackle the virus. However, to reach this, it is crucial to advance our fundamental understanding of the PRRSV biology. In this context, detailed knowledge on the …