Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"early secretory pathway"”.
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Luminal calcium regulates membrane fusion in the early secretory pathway
… luminal calcium, in regulating fusion in the early secretory pathway has not been thoroughly investigated. Here, I show that calcium has an inhibitory effect on homotypic coat protein complex (COPII) vesicle fusion. In particular, chelation of luminal calcium as well as fast chelation of extra …
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Luminal calcium regulates membrane fusion in the early secretory pathway
… luminal calcium, in regulating fusion in the early secretory pathway has not been thoroughly investigated. Here, I show that calcium has an inhibitory effect on homotypic coat protein complex (COPII) vesicle fusion. In particular, chelation of luminal calcium as well as fast chelation of extra …
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Investigating the protein disaggregation machinery in the early secretory pathway
… from a membrane protein and traverses the secretory pathway. While tau is also implicated in AD, particularly affecting the ER-Golgi secretory pathway, recent research highlights the significance of Aβ due to its initial extracellular processing and subsequent re-entry into neurons. …
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The p24 family of putative cargo receptors in the early secretory pathway of a prohormone-producing cell
Contains fulltext : 19035_p24_faofp.pdf (Publisher’s version ) (Open Access)
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P125, A COPII INTERACTING PROTEIN
… for efficient protein trafficking in the early secretory pathway. p125A knockdown also afforded a decrease in membrane association for Sec13 and Sec31A, but not Sec23A. Knockdown of Sec31A results in a redistribution of p125A to the cytosol, indicating that Sec31A is important for the …
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THE ROLE OF P24 PROTEINS IN THE ER TO GOLGI TRANSPORT OF TOLL-LIKE RECEPTORS
… I transmembrane receptors that operate in the early secretory pathway, are involved in the ER to Golgi transport of TLRs. Protein interaction studies performed in HEK293T cells by Proximity Ligand Assay (PLA) reveal that TMED7 interacts with TLR2 and TLR4, but not with TLR3. In contrast, TMED2 …
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Dynamics and Fate of the inner Membrane Complex in Apicomplexan Parasites
… reveals conservation of SNAREs involved in the early secretory pathway, highlighting the stripped-down apicomplexan endomembrane system, and providing a map of SNAREs likely to be involved in distinctive parasite function(s).
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Exploring Endoplasmic Reticulum as a Therapeutic Target Site to Antagonize Amyloid Production.
… of the protein in the organelles of the secretory pathway whilst monitoring its cleavage status. Using pulse-chase long-term fluorescence imaging and analysing the label-signal decay patterns, I quantified APP cleavage within each of these compartments. The measurements demonstrate that …
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Cell Biology of the ICA69 protein family in Neurosecretory cells
… proteins associated with Golgi and post-Golgi secretory vesicles, including insulin secretory granules and synaptic-like microvesicles. Thus, the study of beta-cell autoantigens with yet unknown function may provide novel insight into the secretory machinery of beta-cells and led to the …
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Cornichon Proteins: Unexpected Roles in Plant Pathogen Infection, ER Morphology Maintenance and Pollen Development
Cornichon (CNI) proteins are a conserved family of proteins among eukaryotes, from Erv14 in the yeast Saccharomyces cerevisiae to CNI homologs (CNIHs) in mammals and plants. Erv14 functions as a cargo receptor of coat protein complex II (COPII) for protein trafficking from the endoplasmic reticulum …