Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"early pathogenesis"”.
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Early pathogenesis of Yersinia ruckeri infections in rainbow trout (Oncorhynchus mykiss, Walbaum)
… The aim of this thesis was to study the early pathogenesis of Y. ruckeri infections, with emphasis on the identification of the portal of entry and the investigation of different traits in vitro that have been associated with bacterial virulence. The General Introduction gives an overview …
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Vascular remodelling in malignant hypertension
… is initially asymptomatic, little is known about early pathogenesis. However the principal pathology is vascular remodelling of resistance vessels, termed fibrinoid necrosis, which causes ischaemic end-organ injury. Cardiovascular disease is the leading cause of mortality in western society and …
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Investigating nutrient excess and endothelial dysfunction: a role for BACE1 and amyloid?
… bioavailability, suggesting a role for Aβ in the pathogenesis of ED, but the underlying mechanism is unclear. <br/><br/>One potential mechanism involves mitochondrial dysfunction, whereby mitochondria exhibit impaired bioenergetics, increased reactive oxygen species (ROS) production, and …
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The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes
… dysfunction has been implicated in the early pathogenesis of Type 2 Diabetes. The uncoupling proteins 2 and 3 are mitochondrial proteins found in man that have been implicated in protecting mammals from the effects of over-nutrition. Examination of the effect of genetic variation in the …
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Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
… with outbreak case fatality rates up to 30%. Pathogenesis studies have focused on the later stages of disease, whereas little is known about the influence of the tick-vector in disease outcome. Herein, the role of tick-transmission of CCHFV was investigated to examine the biology and early …
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The role of cerebral small vessel disease in dementia
… cognitive impairment, although its role in the pathogenesis of Alzheimer’s disease (AD) remains poorly understood. Through the investigation of how SVD relates and interacts with (1) molecular AD pathologies and (2) early midlife risk factors of dementia, this body of work aims to advance our …
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The Influence of Obstructive Sleep Apnea Syndrome on Insulin Resistance, Metabolic Syndrome, and Endothelial Dysfunction in Young Men
… OSAS augments the evidence of chronic disease pathogenesis beyond the effects of obesity alone. Subjects: Subjects were 12 overweight men with OSAS (age = 22.8 ± 0.8; BMI = 32.4 ± 1.0; apnea-hypopnea index (AHI) = 25.4 ± 5.4), 17 overweight men without OSAS (age = 22.5 ± 0.7; BMI = 31.6 ± 1.1; …
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The pathogenesis of EHV1 in horses : novel insights from experimental inoculations and field situations
… of this thesis, several important steps in the pathogenesis of this disease were still not fully clarified, making it difficult to find new directions in the strategy to develop better vaccines and to create drugs that inhibit steps of the pathogenesis. In order to achieve this goal, studies in …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… is not fully understood, particularly at the early stages of the disease. Aim and Objectives: To establish and validate an ex vivo rat retinal model and use a multiimmunolabelled approach on the retina to study the effects of hyperglycaemia on the vasculature and cellular components of the …