Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 256 for “"early onset"”.
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Sex-Differences in Early-Onset Alzheimer's Disease
… burden, but this has not been examined in Early-onset AD (EOAD; onset <65). Using data from the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS), we examined sex and apolipoprotein E ε4 (APOE ε4) carrier status as predictors of pathological burden. Methods: Chapter 2 analyses …
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Elucidating the Multi-omics of Early-Onset Colorectal Cancer
<p>The incidence and mortality rates of sporadic early-onset colorectal cancer have increased in recent decades, but there is no clear etiological basis for this trend. EOCRC is commonly defined as colon and rectal cancers diagnosed before the age of 50 years. The rising incidence of EOCRC has made …
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Neuropsychological assessment accuracy in diagnosing early-onset Alzheimer’s disease
<p>Early-onset Alzheimer’s disease (EOAD), a progressive neurological condition, is often difficult to diagnose before substantial neuronal damage. Neuropsychological assessments offer a more cost-effective and accessible method for detecting early cognitive decline, yet limited research exists on …
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Smart Growing Rod Device for the Treatment of Early Onset Scoliosis
Early Onset Scoliosis (EOS) occurs in children under 10 years of age and many cases have a higher probability of progression during growth. The EOS has been treated with “growing rod” procedure to avoid interference with spinal growth. Patients have to undergo a series of operations to have the rod …
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Seasonal sleep patterns among people with early-onset psychosis and university students
… change and sleep patterns in people with early-onset psychosis and university students in Iceland. Three hypotheses were tested 1) Less daylight during winter in Iceland causes worsened sleep patterns. 2) Sleep patterns in young individuals newly diagnosed with psychosis are worse in …
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Quantitative pathophysiology in rabbit models of early onset scoliosis and expansion thoracoplasty
Early onset deformity of the spine and chest wall (initiated <8 years of age) is associated with declining respiratory function and increased morbidity at adulthood relative to adolescent onset deformity of comparable severity. In young children it is presumed that inhibition of thoracic growth …
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Early onset of age related hearing loss in LDHB knock out mouse
… to deletion of LDHB gene in mouse caused early onset of age related hearing loss, as increase of high frequency threshold, hair cell death, which are the typical features of Age-related hearing loss. We investigate the molecular mechanism of hearing loss caused by LDHB deficiency by using …
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Living with early-onset dementia: thematic analysis of dementia blogging and autobiography
… of death in the United Kingdom (Matthews, 2016). Early-onset dementia (EOD) is a subset of the dementias affecting people between the ages of forty-five to sixty-five (Mercy, 2008). People with early-onset dementia (PwEOD) can find themselves negotiating very different experiences from those who …
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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
… conducted in South African women diagnosed with early-onset preeclampsia to investigate efficacy, but it found no change in clinical outcome or biomarker concentrations. It was hypothesized that the 40 mg daily oral dose was not enough to achieve therapeutic exposure. This study investigated the …
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Generation and Analysis of Gene-Targeted Mouse Models for Oppenheim's Early-Onset Dyt1 Dystonia
… neurological movement disorder of Oppenheim's early-onset dystonia. The function of torsinA and the role of the mutation in causing dystonia are unknown. To gain insight into these unknowns, we made two gene-targeted mouse models: a knockin Dyt1 DeltaGAG (KI) to mimic the mutation found in DYT1 …
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Pragmatic ability in children with early onset brain damage and children with pragmatic language impairnent
… pragmatically related abilities in children with early-onset brain damage, i.e. children with cerebral palsy (CP) and children with spina bifida and hydrocephalus (SBH), and in a group of children with pragmatic language impairment (PLI). In study I and III children with CP, SBH and PLI were …
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Predictors of Early Onset of Sexual Intercourse in Male and Female Residents of the United States
… disease. This study examines predictors of early onset sexual intercourse in male and female residents of the United States. Methods: A nationally representative sample of N=7,643 females and N=4.928 males ages 15-44 was procured from the 2002 National Survey of Family Growth (NSFG), Cycle …
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Genetic determinants of susceptibility and disease behaviour in early onset Inflammatory Bowel Disease in Scottish children
A series of investigations examining the importance of genetic factors in the development of the inflammatory bowel diseases (IBD) namely Crohn’s disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC) has been undertaken in Scottish children. This has been performed by collection of …
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… remodeling and pathways associated with early-onset Alzheimer’s disease. The <em>Ttr</em> gene was consistently downregulated across all cell types in the hippocampal CA1-3 regions, along with other alterations in Amyloid beta (Aβ) clearance markers such as CST3, APOE, APOE, APOJ/CLU, …
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Identification of novel genetic determinants in the high prevalence early-onset inflammatory bowel disease population in Scotland
… and novel genetic determinants of childhood onset IBD in Scotland. Methods: The existing repository of childhood onset and adult onset IBD patients, established at the Western General Hospital in Edinburgh, was used and expanded. Thus, anatomical location and behaviour of disease were …
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Development of a novel infection model to test CSF1-Fc as a potential therapeutic for early onset sepsis
… that mediate organ damage and dysfunction. Early onset sepsis (EOS) is defined as onset within the first 72 hours after birth. It is caused by ingestion or inhalation of infected fluids either in utero or intrapartum. The only treatments currently available are antibiotics. However, with the …
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