Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"early mammalian development"”.
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DNA methylation in early mammalian development
… DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethylation that lead to totipotency and the subsequent changes to embryonic specification. In Chapter 1, I validate and refine the decades old model for DNA methylation …
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Exploring functional significance of asymmetric DNA methylation in early mammalian development
… It is also crucial for correct embryonic development and the differentiation of embryonic stem cells (ESCs) into diverse cell types. Although in mammals DNA methylation occurs predominantly in the symmetric CG context, it has been shown that certain cell types and tissues (ESCs, oocytes, …
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Role of small RNAs and chromatin in transposable element silencing during global demethylation
… (TEs). DNA methylation is dynamic during early mammalian development, despite being a more static mark in somatic cells. Global hypomethylation is a hallmark of epigenetic reprogramming in mammalian primordial germ cells (PGCs), the early embryo and in naïve embryonic stem cells (ESCs). …
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Cross-species single-cell transcriptomics and its applications in evolutionary and translational research
… to compare gene expression, cell types and developmental programmes across organisms and interpret these transcriptomic observations within a phylogenetic framework. This opens up new possibilities to study the evolution of cell types and infer molecular properties of organisms inaccessible …
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Mechanisms of Foregut Formation in Mus Musculus
… including the positioning of the heart and early brain. However, despite its fundamental role as one of the most significant shape-changing events in early post- implantation development, the mechanisms driving foregut formation remain poorly understood. This study presents the first …
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MicroRNAs : principles of target recognition and developmental roles
… cell populations that express the miRNA during early mammalian development, we attempt to characterize the direct in vivo targets of miR-196 and dissect the molecular underpinnings of the phenotypes observed.
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Dissecting the role of CHD4 in the NuRD and ChAHP complexes
… ATP-dependent chromatin remodeler essential for early mammalian development. Although best known for its role in gene regulation as a core component of the NuRD complex, CHD4 is also found within the ChAHP complex, which contributes to silencing of transposable elements (TEs). CHD4 generally …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
… organisms to gain insight into human health and development. Traditionally, the mouse has been the favoured vertebrate model, due to its experimental and genetic tractability. Non-rodent embryological studies however highlight that many aspects of early mouse development, including the …
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Cell Fate Decisions in the Early Mammalian Embryo
In mammals, successful pre-implantation development leads to the formation of a tri-lineage structure known as the blastocyst, consisting of the epiblast, primitive endoderm and trophectoderm, which will give rise to the new organism, the yolk sac and placenta respectively. These three lineages …