Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"early embryonic development"”.
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CBD & Ethanol Disrupt Early Embryonic Development
… Zebrafish, a viable translational model for embryonic and neural development, is a cost-effective and translational model that has previously been used in drug research. In the present study, zebrafish embryos were chronically exposed to CBD for 10 days. Embryonic development was assessed at …
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Factors Influencing Early Embryonic Development in the Pig
… 30 nM, 100 nM, 300 nM, 1 muM and 3 muM) had no developmental effect on pig embryos, however pig embryos cultured with 3 muM daidzein may improve blastocyst formation over control embryos. Further studies will be required to determine whether higher levels of these phytoestrogens affect embryonic …
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FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
… blastopore and “open-back” defect during embryonic development. Interestingly, overexpression of Dennd5a by microinjection of RNA leads to very similar phenotype.
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Rmi1 Is Essential For Early Embryonic Development and Attenuation of Tumor Development
… deletion of both RMI1 alleles leads to early embryonic lethality before implantation. I then generated RMI1/p53 double knockout mice. After ionizing radiation treatment at 4Gy, RMI1/p53 double-heterzygous mice showed shortened tumor latency and aggressive tumor types when comparing with …
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MicroRNA expression and function during porcine oocyte maturation and early embryonic development
<p>Understanding oocyte maturation and embryo development in the pig is essential to improving farm animal reproduction efficiency. Many reproductive tissues are associated with a high degree of transcriptional and translational turnover that may be in part regulated by non-coding RNA such as …
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Comparative and phylogenetic analysis of the early embryonic development in the phylum Nematoda
Nematodes are excellent models to study early embryonic development, because – at least for many nematodes- eggs are transparent and the development from fertilized egg to hatched juvenile can be visualized directly under the light microscope. In a first part of this thesis a comparative analysis …
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Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development
… revealed that Mcl-1 deficiency leads to embryonic lethality around E3.5 during peri-implantation stage. Strikingly, the study did not detect any increase in apoptotic cells of the blastocyst, indicating a function of MCL-1 beyond regulating apoptosis. Our previous studies revealed an …
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Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
… Daam family of proteins but the role of Daam2 in early embryonic development however remains conflicting as to whether it functions in the canonical or non-canonical Wnt signaling pathway. In this thesis, I cloned and functionally characterized the role of Xenopus Daam2 in the Wnt signaling …
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The Role of Chk2 and Wee1 Protein Kinases during the Early Embryonic Development of Xenopus laevis
… kinases (Cdks). In Xenopus laevis, embryonic cellular divisions (2-12) consist of rapid cleavage cycles in which gap phases, checkpoint engagement, and apoptosis are absent. Upon the completion of the 12th cellular division, the midblastula transition (MBT) begins and the cell cycle …
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Quantitative analysis of the effect of leflunomide on neural crest cell gene regulation during early embryonic development
… compound leflunomide inhibits neural crest development. Leflunomide’s mode of action is to inhibit pyrimidine biosynthesis, thereby, preventing RNA transcription. Neural crest genes are actively transcribed and like many embryonic stem cells and tumour cells genes undergo an increased level …
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MicroRNAs in early embryonic development : dissecting the role of miR-290 through miR-295 in the mouse
MicroRNAs mediate developmental regulation of gene expression via translational repression of target mRNAs. Targeted deletion of the miRNA biogenesis machinery in the mouse has demonstrated essential roles for miRNAs during early development. In this thesis, I have examined the role of a family of …
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Factors affecting the quality and function of the bovine periovulatory follicle
… the cumulus-oocyte complex to progress through early embryonic development, and to investigate the relative effects of estradiol and progesterone on oocyte maturation and early embryo development. Ability of GnRH to elicit an ovulatory response when administered as an epidural was evaluated in …
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
Most embryonal mortality occurs during early embryonic development. Two experiments were designed to study aspects of early embryonic development. Experiment 1 was to determine if early ovine embryos were capable of metabolizing arachidonic acid. Cyclic ewes were estrous synchronized with …
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ESTABLISHMENT IN CULTURE OF MOUSE AND HUMAN STEM CELLS WITH EXPANDED FATE POTENTIAL
… have the capacity to differentiate to the embryonic and both extra-embryonic lineages and are considered functionally totipotent. Until now, it has not been possible to establish stable cell lines that resemble these totipotent-like cells. In this work, I hypothesised that by modulating …
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Priming with Oral Progestin Before Ovulation Induction Facilitates Ovarian Function in the Cat (Felis catus)
… ovarian responsiveness, fertilization, early embryonic development and luteal function in the cat. Fecal hormone monitoring was used to establish an ALT dosage that provides rapid, reversible ovarian suppression with no residual effects on estrous cyclicity. With this information, the …
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The Role of Autophagy in Early Development and Tumor Suppression Using a Zebrafish Model System
… models, important roles for autophagy in development and tumorigenesis have been suggested. Genetic analyses indicate that autophagy is essential for eukaryotic differentiation and development. However, little is known about whether autophagy contributes to morphogenesis during embryonic …
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The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… kinases (Cdks). In Xenopus laevis, early embryonic development consists of twelve rapid cleavage cycles between DNA replication (S) and mitosis (M) without checkpoints or gap phases. However, checkpoints are engaged in Xenopus once the embryo reaches the midblastula transition (MBT). …
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Potential roles for Elf3 in fetal alcohol spectrum disorder and development
… in response to ethanol exposure during early embryonic development. Here we show a number of elf3 target genes that are downregulated during early development in response to ethanol exposure. We also give some insight into the expression pattern of elf3 in relation to zygotic genome …
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The Role of Dax-1 in Regulating Pluripotency in mouse Embryonic Stem Cells
… Dax-1 is highly expressed in pluripotent embryonic stem (ES) cells and shows a correlative reduction in expression as these cells differentiate. While it is known that Dax-1 is expressed in pluripotent mouse ES cells, the precise function of Dax-1 in these cells is not as well understood. …
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Identification and Characterization of a New E1 That Activates Ubiquitin and FAT10
… Furthermore, E1-L2 deficient embryos died before embryonic day 13.5, suggesting that E1-L2 is essential for early embryonic development. Since the FAT10-deficient mice develop normally, it is likely that specific ubiquitination reactions catalyzed by E1-L2 play an important role in animal …
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