Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"early carcinogenesis"”.
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Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo
… of tumor suppression, however, are not clearly understood. Previous research has shown that head and neck squamous cell carcinoma (HNSCC) responds to VD<sub>3</sub>. This thesis used both in vivo and in vitro models to examine the effect of VD<sub>3</sub> in HNSCC. Former work in the …
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Elucidating p53’s physiological and tumourigenic roles
… positive selective retention of p53 in some early stage cancers, suggesting that p53 function is indeed in some way beneficial for nascent tumours. Such inherent antagonistically pleiotropic properties make classical genetic analysis of p53 function complicated – as does the confounding …
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The Effects of Time-Restricted Feeding on Early Phases of Liver and Colon Carcinogenesis
The influence of dietary factors on carcinogenesis, particularly the role of high-fat diets, is well-documented, with such diets contributing to altered lipid metabolism, the development of metabolic stress, and chronic inflammation. Given the growing interest in time-restricted feeding (TRF) as a …
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Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
… acting in a tumor suppressing fashion in early carcinogenesis but switching in a poorly understood fashion to a promoter of cancer progression in later stages. Mutations and loss of function of TGF-β components are common across a variety of cancers. In particular, the expression of …
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The role of space in homeostasis and preneoplasia in stratified squamous epithelia
A major subject of study in biological research is the dynamics of stem cells in squamous epithelia. Given that most common human cancers develop from epithelia, understanding the rules of cell fate decision in these systems is key to explaining not only healthy tissue growth and maintenance but …