Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"early cancer"”.
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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy
Imaging is the only medical tool currently capable of non-invasively capturing detailed, real time and spatially resolved biochemical information in vivo and thus delineating disease so that non-invasive curative resection or treatment of the affected area can take place. Though visible and near …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
"The development of new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for …
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Near real-time early cancer detection using a graphics processing unit
<p>"Automatically detecting early cancer using medical images is challenging, yet very crucial to help save millions of lives in the early stages of cancer. In this work, we improved a method that was originally developed by Yamaguchi et al. from the Saga University in Saga Japan. The original …
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Theory and application of neural and graphical models in early cancer diagnostics
With the recent availability of large training datasets and graphics processing units (GPUs), we address challenges in the application of graphical models and neural networks to prediction sensitive areas such as healthcare. We begin by presenting our work in the context of learning graphical …
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The application of deep learning to nucleus images for early cancer diagnostics
Cancer remains a major concern for patients and early diagnosis can go a long way in treating patients. Current cancer diagnosis usually involves a pathologist looking at tissue slices of patients for specific features associated with cancer prognosis such as nuclear morphometric measures. However, …
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Development of a Fourier Domain Low Coherence Interferometry Optical System for Applications in Early Cancer Detection
<p>Cancer is a disease that affects millions of people each year. While methods for the prevention and treatment of the disease continue to advance, the early detection of precancerous development remains a key factor in reducing mortality and morbidity among patients. The current gold standard for …
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Novel urinary and serological markers of prostate cancer using proteomics techniques: an important tool for early cancer diagnosis and treatment monitoring
In Africa, Prostate cancer (PCa) is the most frequently diagnosed solid organ tumour in males and use of prostate specific antigen (PSA) is presently fraught with diagnostic inaccuracies. Not least, in a multi-ethnic society like South Africa, proteome differences between African, Caucasian and …
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Magnetically Actuated Microrobots for Tissue Elasticity Mapping in Colorectal Cancer Diagnosis
Colorectal cancer is a major global health issue, ranking among the leading causes of cancer-related mortality. Early detection significantly improves patient outcomes; however, current diagnostic methods such as colonoscopy and traditional imaging primarily rely on visual inspection, limiting …
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Unnatural glycopeptides with application on cancer research
… with relevant implications to fight against cancer: mucins, such as mucin-1 (MUC1), and antifreeze glycoproteins. Concerning the first mentioned class, mucins are a family of O-glycoproteins with high molecular weight that serve as cell-surface receptors and sensors. Notably, aberration in …
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Triplex dna receptor-gold nanoparticle conjugates for detection of oxidized dna base
… of aging and some age-dependent disease, such as cancer. Human body have various mechanisms to repair damaged DNA and base-excision-repair is one mechanism for removing those oxidized nucleobases. This mechanism processes in the cells by cutting the oxidized nucleobases from deoxyribose and …
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Differential light scattering spectroscopy measurements for detecting and imaging cancer
… promise for diagnosing the earliest stages of cancer. Light scattering spectroscopy (LSS), the study of single elastic backscattering as a function of wavelength and angle, can detect subcellular structural changes in early cancer. We have developed two novel differential light scattering …
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Design, fabrication and testing of an acoustic resonator-based biosensor for the detection of cancer biomarkers
… is to develop this technology towards an early cancer detection capability. Specifically, I develop a solidly-mounted resonator with thin-film ZnO as my active piezoelectric layer. These resonators undergo an extensive development process to arrive at a final device design and are fully …
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INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
Cancer is a major health challenge worldwide, and inflammation is thought to be an important factor in cancer etiology. The mutational landscape of human cancer is dominated by cytosine to thymine transition mutations, and the primary mechanism for these mutations is the deamination of cytosine and …
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Statistical aspects of elastic scattering spectroscopy with applications to cancer diagnosis
… of human tissue, and thus able to detect early cancer and precancerous changes. This thesis focuses on the statistical issue on how to eliminate irrelevant variations in the high-dimensional ESS spectra and extract the most useful information to enable the classification of tissue as …
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Integrated narrowband guided mode resonance photonic filters for advanced mid-infrared microspectroscopy
… only, enabling many applications including fast early cancer diagnostics, real-time spectroscopic observation, on-chip chemical sensing, and simple/compact mid-IR instrumentation. In this ‘discrete-frequency infrared’ (DF-IR) spectroscopy approach, there is no Fourier transform infrared (FT-IR) …
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Synthesis and detection of dna damage
… 8-oxoGua has been suggested as a biomarker for early cancer diagnosis. An artificial receptor for the free base of 8-oxoGua on a triplex DNA backbone was previously developed. However, accurate detection of 8-oxoGua in urine samples was affected by the presence of a large excess of guanine. …
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Capillary electrophoresis of pteridines in urine and plants and quantification of pharmaceutical and personal care products in Missouri waste water
… (PPCP's) in Missouri waste water.</p> <p>As cancer continues to be one of the top three causes of human fatalities, early cancer screening research continues to gain momentum. One specific category of compounds known as pteridines is a class of compounds with potential linkage to cancer …
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Solid-state nanopore sensors for nucleic acid analysis
… methylation patterns in panels of genes for early cancer detection, and the creation of lipid bilayer coated nanopore sensors, useful in creating hybrid biological/solid-state nanopores for DNA sequencing applications. The concept of a gated nanopore is also presented with preliminary …
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INFERRING TUMOR PROPERTIES FROM GENE EXPRESSION DATA
… improved the use of transcriptome data in cancer research, benefiting both diagnostic and prognostic clinical applications. Gene expression is used to predict the tissue of origin (TOO) of tumor samples, which is relevant in several scenarios such as the diagnosis of cancer of unknown …
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Dual-modality thermoacoustic and photoacoustic imaging
Diagnosis of early breast cancer is the key to survival. The combined contrasts from thermoacoustic and photoacoustic tomography: TAT and PAT) can potentially predict early stage breast cancer. We have designed and engineered a breast imaging system integrating both thermoacoustic and photoacoustic …
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