Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"eRNA"”.
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Acute Manipulation of Erna Level For Dissecting Its Roles In Transcriptional Regulation
… non-coding transcripts named enhancer RNAs (eRNAs). These created a new challenge to understand enhancer functions, which now are not only DNA elements that promote transcription but also RNA-producing transcription units themselves. Importantly, deregulation of eRNAs was associated with …
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ROLE OF A SPECIFIC NANOG SUPER-ENHANCER ERNA IN EPIGENETIC REMODELING AND ENHANCER-PROMOTER INTERACTION
… gene regulation. In this work, the role of eRNAs transcribed from the region 5kb upper the TSS of Nanog gene in mESCs has been investigated. In particular, a specific eRNA transcript, here defined as antisense eRNA, resulted actively involved in the maintenance of Nanog gene in an active …
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An exploration of the portrayal of the Girl-Child in Erna Muller's it all goes wrong and when you dance with the crocodile
… analysis of the portrayal of the girl-child by Erna Muller in It all goes wrong and When you dance with the crocodile. The two novels were selected using purposive sampling as they primarily characterise girl-children as protagonists. The researcher employed the African feminist literary theory …
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Manipulating Enhancer Rna Activity to Study Their Roles In Gene Regulation and Cancer
… into RNAs, which are named enhancer RNAs (eRNAs). Studies have suggested that eRNAs have a functional role in the enhancer action mechanism. Studying their roles will provide a new understanding of gene regulation and cancer development. In my MS study, I focused on using novel methods to …
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… we referred to as fibrotic enhancer-associated eRNAs. I further conducted an eRNA perturbation experiment that supported a role of key enhancer and eRNA in activating fibrotic genes in HSC cells. Findings here support the identification and interrogation of functional enhancers that drive …
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Inscrutable Islands: Narrative Difficulty and the Rhetoric of Creolization in Twentieth-Century Caribbean Novels
… However, in the novels of Patrick Chamoiseau, Erna Brodber, Jean Rhys, Maryse Condé, Édouard Glissant, and Wilson Harris, difficult narrative forms can instead entrench social divisions and hierarchies.</p>
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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
… (H3K9me3) to 'active' (H3K9ac) that allows for eRNA production. In support of this hypothesis, we observe that JMJD2d is tightly associated with enhancers in the genome and preferentially binds active enhancer regions. Taken together, JMJD2d represents the first example of a chromatin modifier …
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CRISPR-based Transcriptional Activators for Dissecting Human Gene-Regulatory Mechanisms
… aspects of transcription regulation, including eRNA transcription, mRNA transcription, histone acetylation and chromatin spatial rearrangement. We used dCas9-based activators to demonstrate that an intrinsic transcriptional and epigenetic reciprocity can exist between human enhancers and …
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"Sometimes Folk Need More": Black Women Writers Dwelling in the Beyond
… dialogue in Toni Morrison's, <em>Paradise</em>, Erna Brodber's, <em>Louisiana</em>, Kasi Lemmons' film, <em>Eve's Bayou</em>, and Danzy Senna's short story, "The Land of Beulah." Each of these texts suggest that not only do promises of protection leave characters needing "something more," but …
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The virgin's daughters: Catholic traditions and the post-colonial south in contemporary women's writing
… Sisterhood, Brenda Marie Osbey’s All Saints, and Erna Brodber’s Louisiana. The authors enact spiritual and cultural reclamation through the written expression of key components of postcolonial reconstruction of history, including ancestral memory, hybridization of cultural narratives, and …
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The Influence of Literacy on the Lives of Twentieth Century Southern Female Minority Figures
… in her life, including racism and sexual abuse. Erna Brodber's 1994 novel Louisiana provides an interesting look at a young woman's attempts to enter unfamiliar multicultural southern communities. In the process, she must learn new literacies as she works to complete the oral history project she …
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Uncivilized women and erotic strategies of border zones or demythologizing the romance of conquest
… adapting to colonization. Chapter three examines Erna Brodber's Myal and the impact of the manichean colonial ideology on a Jamaican woman who is literally half-black and half-white. Chapter four addresses Julia O'Faolain's No Country for Young Men, a novel about two women, one who lived through …
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A sequential evaluation of left ventricular function in asymptomatic and symptomatic patients with chronic severe aortic regurgitation
… and equilibrium radionuclide angiocardiography., ERNA) have been serially utilised~ In these endeavours, the thinking has been clouded by a tendency to equate these two measures and failing to appreciate that apparent preoperative LV dysfunction (particularly on exercise) may be rapidly reversible …
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Framing Standard and Dialect in Black Women's Novels
… With double exposure in Louisiana (1994), Erna Brodber uses Hurston as the inspiration for her fictional main character to ground her theories in the Black diaspora. Toni Morrison invests in Black women's discursive erasure as the material of reorientation, presenting a photonegative in …
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Contextualizing narrative theory: reading the politics of formal innovation in contemporary women's fiction
… and the limitations of others. It opens up alternative critical possibilities by drawing upon insights within contemporary critical theory, from poststructuralist philosophy to transcultural feminism to sociolinguistics. Above all, my interventions proceed from close readings of innovative …
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
… generate ncRNAs that are termed enhancer RNAs (eRNAs). Emerging studies illustrated that at least some eRNAs can recruit transcriptional regulatory proteins and promote enhancer-promoter interaction to enhance the transcription of the target genes. In cancers, the dysregulation of eRNAs is …
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A túlélő házastárs öröklésjogi helyzete a magyar és a román jogrendszerben
A szakdolgozat a túlélő házastárs öröklésjogi helyzetét hasonlítja össze a magyar és a román jogrendszerben. Bemutatja párhuzamosan: a törvényes öröklési rendet, ezen belül a túlélő házastársat, az arányokat és a feltételeket; majd a végrendeleti öröklés sajátosságait; végül a túlélő házastársat …
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Construction of inducible expression systems for controlled transfer of Agrobacterium tumefaciens T-DNA in plant transient expression systems /
… applications are still desirable as a cheaper alternative. Biosafety concerns related to the use of recombinant agrobacteria in an industrial transfection process include possible transformation/transfection of unintended hosts or spread of the genetically modified agrobacteria in the environment. …
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Pengaruh konsentrasi dan lama perendaman dalam larutan asam sulfat (H2SO4) terhadap pematahan dormansi biji sengon (Paraserianthes falcataria L. Nielsen)
… pertahunnya, maka diperlukan tanaman alternatif yang mampu menghasilkan kayu secara cepat untuk memenuhi kebutuhan kayu di indonesia. Dalam hal ini sengon sangat penting untuk dikembangbiakan, perkembangbiakannya dapat dilakukan dengan menggunakan biji. Akan tetapi masalah utama …
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