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Showing 1 to 6 of 6 for “"eQTL mapping"”.
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Causal Gene Network Inference from Genetical Genomics Experiments via Structural Equation Modeling
… using expression Quantitative Trait Loci (eQTL) mapping and Structural Equation Modeling (SEM). Unlike Bayesian Networks, this approach is able to construct cyclic networks, while cyclic relationships are expected to be common in gene networks. Reconstruction of gene networks provides …
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Using single-cell RNA-seq to assess the effect of common genetic variants on gene expression during development
… called expression quantitative trait loci (eQTL). Recent advances in experimental techniques have provided an unprecedented opportunity to measure gene expression at the single cell level, and the chance to study cellular heterogeneity. This represents a remarkable advance over traditional …
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Regulation of gene expression in macrophage immune response
Gene expression quantitative trait loci (eQTL) mapping studies can provide mechanistic insights into the functions of disease-associated variants. However, many eQTLs are cell type and context specific. This is particularly relevant for immune cells, whose cellular function and behaviour can be …
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Statistical Modeling Approaches For The Inference of Cancer Mechanisms
… expression quantitative trait loci (eQTL) mapping framework accounting for impure tumor samples and copy number alterations. eQTL analysis is a powerful tool for understanding the genetic basis of complex traits. However, existing methods do not account for copy number alterations in …
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Understanding the role of CD4+ T cells in common immune-mediated diseases
… expression quantitative trait locus (sc-eQTL) mapping study performed on CD4+ T cells undergoing activation. I identify over 6,000 genes regulated by an eQTL, of which approximately 2,000 show evidence of a gene-by-environment interaction, where the eQTL effect size changes as a function …
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GENOMIC AND MICROBIOME ANALYSIS TO IMPROVE FILLET YIELD AND QUALITY TRAITS IN RAINBOW TROUT
… integrated expression quantitative trait loci (eQTL) mapping to connect genetic variants with gene expression and phenotypic outcomes. A total of 6,275 cis-eQTLs were identified near promoter regions influencing gene expression. Notable candidate genes included GABRR1-like, AZIN1, and ATP6V1 for …