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Showing 1 to 5 of 5 for “"eIF5B"”.

  1. Elucidating the role of eukaryotic initiation factor 5B (eIF5B) in non-canonical translation initiation

    … through uORF- mediated translation initiation. eIF5B has been shown to deliver initiator-tRNA during non-canonical translation initiation. As such, we defined the role of eIF5B in the non-canonical translation of ATF4, and p27. Through polysome profiling and luciferase reporter assays, we …

    lethbridge Repository record for Elucidating the role of eukaryotic initiation factor 5B (eIF5B) in non-canonical translation initiation (opens in a new tab)

  2. Establishing and optimizing a pipeline for using a combined multi-omic approach to assessing the role of eIF5B in glioblastoma cells

    … changes. Previously, we demonstrated that eIF5B is responsible for the translation of a subset of mRNAs encoding anti-apoptotic proteins which regulated the sensitivity of U343’s resistance to TRAIL. Through this project, I have established an important multi-omics pipeline for …

    lethbridge Repository record for Establishing and optimizing a pipeline for using a combined multi-omic approach to assessing the role of eIF5B in glioblastoma cells (opens in a new tab)

  3. Mathematical modeling of eIF5B-mediated non-canonical translation initiation as a chemotherapeutic target

    lethbridge

  4. Investigating the role of eukaryotic initiation factor 5B (eIF5B) in oral squamous cell carcinoma

    lethbridge