Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"eIF4G"”.
-
The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors
… depends on eukaryotic initiation factor eIF4G. BTE binds to eIF4G; however, the details of BTE initiated translation are still unclear. Three eIF4G deletion mutants with different domain organization were used to investigate BTE interaction with eIF4G: eIF4G601-1196 is the eIF4G fragment …
-
The Role of Secondary and Tertiary Structure in the Cap-Independent Translation of FGF-9 and HIF-1-alpha
… involving eukaryotic initiation factor 4G (eIF4G) binding directly to the 5’ untranslated regions (5’ UTR) of the RNA. eIF4G binding then recruits the ribosome to the transcript. While this mechanism is useful for translation of apoptotic transcripts and transcripts involved in cell …
-
A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease
… showing that it makes surgical strikes against eIF4G and Nup98, key players in host protein synthesis and nucleocytoplasmic trafficking of proteins and RNA, respectively. We subsequently utilized those protease expression platforms in combination with transport reporter assays to interrogate …
-
The Effect of Post Exercise Nutrition on Anabolic Response to Resistance Exercise
… exercise bout increased the amount of eIF4E-eIF4G by 4.5% 1-hr postexercise (p<0.05) without affecting the amount of eIF4E-4E-BP1. One hour after beverage consumption, serum total amino acid concentration increased for MILK 1 (p=0.003) and MILK 2 (p<0.001) but decreased for CE (p=0.028) and …
-
Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… Looking at the induced binding of Mnk1 to eIF4G, we found that the dissociation rate varies depending on the activating pathways. This shows that Mnk1 is not a true convergence point of p38 and Erk1/2 MAPK pathways resulting in identical downstream effects, but that Mnk1 mediates pathway …
-
Identificação de parceiros funcionais e propriedades do fator EIF4E5, homólogo do fator de iniciação da tradução EIF4E (EIF4E5) de Leishmania infantum
… que o EIF4E5 interage especificadamente com o EIF4G1, homólogo de outra subunidade do complexo eIF4F, o eIF4G. Outras interações com proteínas de modificação de mRNAs e ligadas a vias de sinalização também foram identificadas, mas várias destas interações foram abolidas quando foi mutado um …
-
Determinants of translational efficiency in Saccharomyces cerevisiae
… factor, yeast eukaryotic initiation factor 4G (eIF4G), contributes to genome-wide competition between mRNAs. Finally, I will discuss future directions for this work.
-
Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)
… and stability of the complexes are important. 7. eIF4G, a subunit of eIF4F, binds to IRE-RNA without other subunits. A novel regulatory mechanism is proposed where metabolic iron (Fe<sup>2+</sup>) induces IRE-RNA conformation change to decrease inhibitor protein (IRP) binding and increase …
-
Protein quality and distribution determines anabolic signaling, cellular energetics, and body composition
… factor eIF4E and allows it to bind with eIF4G. Binding of eIF4E with eIF4G promotes preparation of the mRNA for binding to the 43S pre-initiation complex. Consumption of the amino acid leucine (Leu) is a key factor determining the anabolic response of muscle protein synthesis (MPS) and …
-
Regulation of protein metabolism in skeletal muscle of low-birth-weight neonatal pigs
… factor (eIF) 4F complex subunits, eIF4E, eIF4G, and eIF4A was reduced in LBWT compared with NBWT pigs. This would suggest that diminished translation initiation signaling in skeletal muscle of LBWT pigs is the main factor that predisposes LBWT pigs to slower growth rates in the neonatal …
-
Mechanisms of persistent translation arrest following global brain ischemia and reperfusion
… mRNA granules were found to only colocalize with eIF4G, PABP and HuR, suggesting that mRNA granules may itself be related to or a subset of the ELAV/Hu granule.</p> <p>6. HuR co-localized to mRNA granules and translation of HSP-70. This correlation suggests mRNA granules are involved in …
-
Identification and stoichiometric analysis of the monosomal translational complex
… components of the closed-loop structure, eIF4E, eIF4G1/eIF4G2 and PAB1. The abundance of 77S complexes decreased with translational defects and following the stresses that cause translational stoppage. By quantitating the abundance of the 77S complex in response to different stress conditions, I …
-
CHARACTERIZATION OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (eIF4E) FAMILY MEMBERS IN THE ZEBRAFISH (Danio rerio)
… initiation factor eIF4E-1. eIF4E-1 binds eIF4G to initiate translation, a process inhibited by eIF4E binding proteins such as the 4E-BPs and other eIF4E interactive proteins. Analysis of eIF4E sequences from the twenty fish genomes currently available, as well as those of echinoderm, …
-
Translational tuning pre-emptively modulates protein folding and secretory pathway defects
… loss of the yeast translation initiation factor eIF4G is beneficial. Synthesis defects in eap1 cells can be rescued by reducing ribosome abundance, or by impairing the RQC pathway. This suggests ribosome collisions as a causative factor for reduced Yor1 biogenesis in the absence of Eap1. I …
-
Post-transcriptional regulation of poly(A) binding proteins direct multiple facets of cardiac development and hypertrophy
… translation rates through its interaction with eIF4G to enable translation through the closed-loop model. In biochemical and transcriptome-wide studies, PABPN1 was determined to be a primary effector of post-transcriptional events of maturational and adult hypertrophy related genes through …
-
eIF4E Phosphorylation Balances Cap-dependent and Cap-independent Translation Initiation
<p>Signaling pathways converge on the translation machinery and influence protein synthesis globally or specifically on certain classes of transcripts. The experiments described in this thesis focus on regulation of translation initiation through the cap-binding protein eIF4E. </p><p>Aberrant …
-
Direct Recruitment of eIF4GI and/DAP5 to the 5' UTR of a Subset of Human mRNA Drives Their Cap-independent Translation
… has also been correlated with increased eIF4GI and its homolog, Death Associated Protein 5 (DAP5) expression levels, suggesting these factors have a role in cap-independent translation. Despite several evidence pointing towards a link upregulation of eIF4GI and /DAP5 levels during stress …