Global ETD Search
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Showing 1 to 11 of 11 for “"eIF4F"”.
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Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)
… shows 1. Eukaryotic initiation factor 4F (eIF4F) binds to IRE-RNA with high affinity and works as a positive control element in mRNA translation. 2. eIF4F, IRP competitively bind to IRE-RNA. 3. Fe<sup>2+</sup> increases eIF4F/IRE-RNA binding affinity, which outcompetes IRP binding. 4. …
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Eukaryotic Initiation Factor 3 Interactions with Structural Elements of Barley Yellow Dwarf Virus Untranslated Regions Reveal Details of a New Cap-Independent Translation Initiation Model
… capable of recruiting the cap-binding complex eIF4F, the large scaffolding complex eIF3, and the 40S ribosomal subunit. Together eIF3, eIF4F, and BTE influence factor binding and 40S recruitment on the 5′ UTR and play a key role in facilitating BYDV translation. This report focuses on eIF3 by …
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Elucidating the Roles of Eukaryotic Initiation Factors Involved in DAP5 Mediated Translation
… be mediated by the eukaryotic Initiation Factor (eIF4F), which consists of the cap binding protein eIF4E, the scaffolding protein eIF4GI, and the helicase factor eIF4A.The recognition and binding of eIF4E to the m<sup>7</sup>G cap structure of the mRNA is essential for the subsequent recruitment …
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Identificação de parceiros funcionais e propriedades do fator EIF4E5, homólogo do fator de iniciação da tradução EIF4E (EIF4E5) de Leishmania infantum
… sua função. Dentre esses, destaca-se o complexo eIF4F, onde a subunidade eIF4E é a responsável pelo reconhecimento dos mRNAs por meio de sua extremidade 5 Nos tripanossomatídeos, protozoários parasitas de importância médica, sua expressão gênica é regulada pós-transcricionalmente e durante a …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
… recently discovered small molecule inhibitor of eIF4F formation. During our investigations it was discovered that protein synthesis in primary cells was minimally dependent upon eIF4F yet highly sensitive to 4EGi-1 at concentrations that did not alter eIF4F levels but instead, increased the …
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A multi-level approach to understanding the regulation of translation initiation
… which ultimately results in the disruption of eIF4F, a multiprotein initiation factor complex that coordinates the recruitment of the small ribosomal subunit to the 5' end of mRNA. Like a decrease in the amount of ternary complex, disruption of eIF4F also suppresses translation of most mRNAs; …
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On the function of the interferon-inducible p53 target gene TRIM22
… initiation factor eIF4E and disruption of the eIF4F-complex. My data suggest that TRIM22 may suppress translation of a subset of mRNAs, particularly dependent on eIF4F for their translation. In paper III I show overexpressed TRIM22 to induce either repressed proliferation or cell-death …
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Protein quality and distribution determines anabolic signaling, cellular energetics, and body composition
… assembly of the eukaryotic initiation factor 4F (eIF4F) complex and phosphorylation of the 70 kilodalton ribosomal protein S6 kinase (S6K1). Assembly of the eIF4F initiation complex involves phosphorylation of the inhibitory eIF4E binding protein-1 (4E-BP1), which releases the initiation factor …
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Studying sequence effects of mRNA 5' cap juxtapositions on translation initiation rate using randomization strategy of the extreme 5' end of mRNA
… capped 5’end of mRNA, facilitated by m7G cap – eIF4F interactions. The PIC accommodation onto the 5’end of mRNA is a point of control in translation initiation where the role of 5’ cap proximal mRNA sequence determinants are poorly understood. To explore the effect of the nucleotides in the …
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On the expression, function and regulation of the murine Ifit family of antiviral RNA-binding proteins.
… translation initiation factor complex eIF4F. IFIT1 is highly specific for ‘non-self’ cap0 RNA, which lacks methylation on the first and second cap-proximal nucleotides, but at high concentrations may also restrict ‘self’ cap1 translation. Knock-out mouse models have been extensively …
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The Interplay of RSV and IFITs: A comprehensive analysis of human and bovine Interferon-Induced Proteins with Tetratricopeptide Repeats induction and interaction with human and bovine Respiratory Syncytial Virus
… them for viral benefit (e.g., components of the eIF4F complex) or inhibiting their function (e.g., MAVS and MDA5). Our study aimed to determine if the IFITs are induced during RSV infection and thus provide support that their reported ectopic inhibition of RSV is relevant *in vivo*. Additionally, …