Global ETD Search
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Showing 1 to 8 of 8 for “"eIF4A"”.
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The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors
… including binding domains for eIF4E, central eIF4A, eIF4B and the possible BTE binding region; eIF4G601-1488 is a longer fragment with one additional C-terminal eIF4A binding domain; eIF4G742-1196 is a shorter deletion mutant lacking the eIF4E binding sequence. eIF4G601-1196 binds BTE as …
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Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
… stromal cells (BMSCs) become a source of eIF4A-cap-dependent translation machinery that is transferred to AML cells via extracellular vesicles (EVs), to meet their translational demands. In two independent models of highly chemo-resistant AML driven by MLL-AF9 or FLT3-ITD;NPMc mutations, …
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Elucidating the Roles of Eukaryotic Initiation Factors Involved in DAP5 Mediated Translation
… protein eIF4GI, and the helicase factor eIF4A.The recognition and binding of eIF4E to the m<sup>7</sup>G cap structure of the mRNA is essential for the subsequent recruitment of eIF4GI and eIF4A to form a translationally active eIF4F complex. During stress conditions in the cell such as …
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Regulation of protein metabolism in skeletal muscle of low-birth-weight neonatal pigs
… (eIF) 4F complex subunits, eIF4E, eIF4G, and eIF4A was reduced in LBWT compared with NBWT pigs. This would suggest that diminished translation initiation signaling in skeletal muscle of LBWT pigs is the main factor that predisposes LBWT pigs to slower growth rates in the neonatal period. In …
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Direct Recruitment of eIF4GI and/DAP5 to the 5' UTR of a Subset of Human mRNA Drives Their Cap-independent Translation
… for the additional initiation factors (eIF4A, eIF4B and eIF4E) required by these mRNAs for their cap-independent translation initiation, adding to our understanding of these different cap-independent translation mechanisms. Collectively, the quantitative binding- and <em>in vitro</em> …
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Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
… </p> <p>eIF4B enhances the helicase activity of eIF4A during translation initiation. As expected, knockdown of eIF4B expression decreased cell viability comparable to the decrease observed with the combination treatment. Importantly, we have identified p70S6K and p90RSK as kinases directly …
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
Cancer treatments often target singular oncoproteins in attempt to block one hallmark of cancer and stop tumor growth and progression. However, although these treatments are often initially effective, many cancer patients develop resistance and experience relapse due to redundant signaling or tumor …
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Herbicide safeners: upregulating detoxification mechanisms for selective weed management in grain sorghum (Sorghum bicolor L. Moench)
… expressed reference genes: GTPB, SAND, and EIF4a. Results indicated expression of each SbGST gene increased within 12 hr following safener treatment but differed by specific gene and genotype, suggesting these SbGSTs play a functional role in the safening response from herbicides. Chapter 3 …