Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"eIF2alpha"”.
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In Vitro and In Silico Analysis of Osteoclastogenesis in Response to Inhibition of De-phosphorylation of EIF2alpha by Salubrinal and Guanabenz
… translation initiation factor 2 alpha (eIF2alpha), which regulates efficiency of translational initiation. The elevation of phosphorylated eIF2alpha was reported to stimulate osteoblastogenesis, but its effects on osteoclastogenesis have not been well understood. Using synthetic chemical …
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Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… of eukaryotic initiation factor 2alpha (eIF2alpha), which results in selective translation of mRNAs encoding stress response proteins. Post-transcriptional control of gene expression is suspected to play an important role in P. falciparum. Importantly, the Goldberg laboratory recently …
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Identifying novel proteins in translation complex by using analytical ultracentrifugation with fluorescent detection system
… 5'-UTR of CLN2 mRNA. Components of the eIF3 and eIF2alpha complex were also found to be part of the 78S complex, although formaldehyde cross-linking was required to stabilize their association with this complex. These results confirm the utility of AU-FDS for charactering the constitution of …
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The Genetic Basis Of Neurodegenerative Diseases: The Role Of Sel1L In Tau Pathology And Neuropathology
… neurological disorders, an inhibitor of the eIF2alpha kinase (PERK) branch of the UPR was administrated to Sel1l-NKO mice, which slightly improved their motor function performance. Collectively, our data suggest that dysfunction of SEL1L, via sustained UPR and tau pathology, induces …
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Regulation of Pkr Activation by Pact and Trbp In Response to Stress Signals
<p> PKR (protein kinase, RNA activated) is an interferon (IFN)-induced serine-threonine protein kinase, which plays a crucial role in IFN's antiviral and antiproliferative actions. In addition, PKR plays a regulatory role in signal transduction leading to apoptosis in response to a variety of …
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
<p> <p> Pancreatic ductal adenocarcinoma (PDAC) represents the fourth most common cause of cancer-associated death in the United States. Little progress has been made in understanding how proteotoxic stress affects rapidly proliferating pancreatic tumor cells. Endoplasmic reticulum (ER) stress …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
<p>The mechanisms underlying cellular response to proteasome inhibitors have not been clearly elucidated in solid tumor models. Evidence suggests that the ability of a cell to manage the amount of proteotoxic stress following proteasome inhibition dictates survival. In this study using the …
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The cue induced axonal nascent proteome and its translational control mechanisms in neural wiring
Axonal protein synthesis is rapidly regulated by extrinsic cues during neural wiring but the full landscape of proteomic changes and their translational control mechanisms remain unknown. The ability to investigate the nascent proteome on subcellular compartments has been hampered by the low …