Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"eIF2"”.
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The eIF2 phosphatase: characterization and modulation
… protein synthesis is the phosphorylation of eIF2, which triggers the so-called Integrated Stress Response (ISR). Kinases that sense stresses induce the phosphorylation of eIF2, which, on the one hand, attenuates global rates of protein synthesis and, on the other hand, activates the …
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GCN2 eIF2 Kinase Promotes Prostate Cancer by Maintaining Amino Acid Homeostasis
… the eukaryotic translation initiation factor 2 (eIF2) during different stress conditions, repressing global protein synthesis. In parallel, eIF2 phosphorylation also enhances the translation of select gene transcripts, such as ATF4, which directs the transcription of ISR-target genes critical for …
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Investigating The Role of Pancreatic eIF2-alpha kinase (PEK) In DLK/ Wallenda (Wnd)-mediated Neurodegeneration In Drosophila
Neurons, the cells that are electrically excitable and form the basis of the nervous system, display an impressive range of morphologies and functions, which together drive processes from sensation and movement to cognition. These unique and mighty cells also have developed unique features such as …
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Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans
… (UPR) and translational control mediated by eIF2[alpha] phosphorylation. While the cell-autonomous functions of these stress-responsive mechanisms in maintaining cellular homeostasis have been examined, their organismal effects on remodeling development and stress responses remain largely …
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The mechanisms regulating the transcription factor ATF5 and its function in the integrated stress response
… of eukaryotic initiation factor 2 (eIF2) is an important mechanism regulating global and gene-specific translation during different environmental stresses. Repressed global translation by eIF2 phosphorylation allows for cells to conserve resources and elicit a program of gene …
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A MOLECULE-INHIBITOR OF THE INTEGRATED STRESS RESPONSE REGULATES ACTIVITY OF MAMMALIAN EUKARYOTIC TRANSLATION INITIATION FACTOR 2B
… of eukaryotic translation initiation factor 2 (eIF2) that inhibits the guanine nucleotide exchange activity of its partner eIF2B and attenuates overall rates of protein synthesis. Numerous mutations in eIF2B are linked to a fatal neurodegenerative disease of vanishing white matter. A new …
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Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2
… in mammals. Unlike eIF4GI/II, DAP5 binds eIF2β, a subunit of the eIF2 complex that delivers methionyl-tRNA to ribosomes. Despite extensive work describing eIF4GI, an understanding of DAP5 activation is yet to be described. </p><p> Here I describe our discovery that DAP5:eIF2β binding is …
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The response of eIF2α kinases to plant virus infection
… eukaryotic translation initiation factor 2 α (eIF2α) is phosphorylated in several eukaryotes, general mRNA translation is inhibited, but some mRNA species that contain an upstream open reading frame (uORF) are preferentially translated. In plants, two types of eIF2α kinases have been reported - …
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A study of mRNA translation with computational analysis of ribosome profiling datasets
… to examine the translational response to eIF2 repression and to the deprivation of oxygen and glucose respectively. Chapter 4 details how the interaction of the Shine Dalgarno with the ribosome rRNA alters the length of the mRNA protected fragments. In Chapter 5, I present analysis at …
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The effect of alternative splicing on key regulators of the integrated stress response
… the α subunit of eukaryotic initiation factor-2 (eIF2), a translation factor that delivers initiator tRNA to ribosomes. Phosphorylation of eIF2α inhibits general translation, which conserves energy and nutrients and facilitates reprogramming of gene expression for remediation of stress damage. …
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Regulation of Pkr Activation by Pact and Trbp In Response to Stress Signals
… of the translation initiation factor eIF2α and cellular apoptosis. In addition to positive regulation by PACT, PKR activity in cells is also negatively regulated by human immunodeficiency virus trans-activating region (TAR) RNA-binding protein (TRBP). The purpose of this study is …
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Modeling Complex Neurological Disorders With Human Induced Pluripotent Stem Cells
… We found that infection led to activation of EIF2 in all three cell types, which was largely resolved by treatment with the antiretroviral compound efavirenz (EFZ). However, EFZ treatment enhanced distinct inflammation signatures and TNFa production in HIV-infected microglia. These findings …
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Structural and Functional Characterisation of the Nutrient Sensing Kinase GCN2
… phosphorylates the translation initiation factor eIF2, initiating the Integrated Stress Response. This causes the global inhibition of protein synthesis and the upregulation of stress response pathways. GCN2 has been implicated in a wide range of cellular processes in health and diseases, …
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Essential Amino Acid Regulation of Cell Signaling and Casein Synthesis in Mammary Tissue
… of Ile, Leu, Met, or Thr had<br />no effect on eIF2" phosphorylation. Isoleucine positively affected mTOR, and rpS6, and<br />negatively affected eEF2 phosphorylation. Leu had a similar effect on eEF2, but not on<br />mTOR or rpS6, and these two AA inhibited each other. Thr negatively interacted …
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Papel de YAP/TAZ en la respuesta de células tumorales a estímulos activadores de receptores de TRAIL
… endoplásmico) confluyen en la fosforilación de eIF2?, el elemento clave de la ISR, que disminuye la síntesis global de proteínas y facilita la traducción de proteínas que participan en la recuperación de la homeostasis. La privación de glutamina provoca un aumento de actividad del complejo …
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Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell
… of eukaryotic translation initiation factor 2 (eIF2)a via the protein kinase RNA-like endoplasmic reticulum (ER) kinase (PERK) and the appearance of stress granules, indicating translational attenuation. Likewise, a TNF-α response to lipopolysaccharide (LPS) was inhibited when this toll-like …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… geni correlati ai pathway Fitness-OverT, tra cui eIF2, eIF3, CSTF e CPSF, in una coorte locale di CRC, nei campioni di adenocarcinoma del colon (COAD) del The Cancer Genome Atlas (TCGA) e nei modelli cellulari. La caratterizzazione molecolare delle linee cellulari di carcinoma colorettale è stata …
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Driver genes associated to Broad Copy Number Aberrations in solid cancers
… that some multi-subunit protein complexes (eIF2, eIF3, CSTF and CPSF) are candidate targets for silencing transcriptional therapy. At the end, in Glioblastoma multiforme the most recurrent chromosome aberration regards the gain of chromosome 7 alone or in combination with focal amplification …