Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"eEF1A"”.
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Role of eEF1A-2 in the pathogenesis of Motor Neurone Disease
… patients. I have also screened the human gene, EEF1A2, for mutations in both familial and sporadic patients. Although there were polymorphisms within the gene which were also present in healthy controls, there were no mutations. It is thus unlikely that mutations in EEF1A2 are responsible for …
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A novel function for the eukaryotic translation elongation factor 1A
The eukaryotic translation elongation factor 1A, eEF1A, a homolog of the bacterial EF1A (formerly known as EF-Tu), is a well-characterized ribosome associated factor, responsible for the delivery of aminoacyl-tRNAaa to the ribosomal A site. In contrast to this indirect interaction with the nascent …
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THE ROLE OF TRANSLATION ELONGATION DEFICITS IN ALZHEIMER’S DISEASE PATHOGENESIS
… of elongation, eukaryotic elongation factor 1A (eEF1A) and eukaryotic elongation factor 2 (eEF2). Hippocampal eEF1A expression was diminished in human AD patients and transgenic AD model mice. Furthermore, treatment with amyloid beta (Aβ) significantly reduced eEF1A expression in acute …
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NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
… NSs, and eukaryotic Elongation Factor 1 Alpha (eEF1a) suggest a role of this host factor in the SFTS virus lifecycle. Subcellular localization of eEF1a in the context of SFTS virus infection showed high levels of colocalization. Treatment of infected cells with the eEF1a inhibitors Didemnin B …
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Investigating the role of eEF1A2 in motor neuron degeneration
… the eukaryotic translation elongation factor 1A (eEF1A) has been implicated in disease states such as motor neuron degeneration and cancer. Two variants of eEF1A are found in mammals, named eEF1A1 and eEF1A2. These two variants are encoded by different genes, produce proteins which are 92% …
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Characterisation of cardiac protein changes post death: pilot study
… I, vinculin, and eukaryotic elongation factor (eEf1a) and their degradative products were evaluated in cardiac tissue using Western blot(WB) assay from decedents recruited at the Salt River Mortuary(SRM), Cape Town. The native and degradative products of these proteins were compared between …