Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"eDNA libraries"”.
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Natural Product Biosynthesis In Uncultured Bacteria
… extracted directly from environmental samples (eDNA) has begun to provide access to the chemical diversity encoded in the genomes of previously uncultured bacteria. The systematic exploration of natural product biosynthesis in uncultured bacteria, however, still faces several challenges that we …
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Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
… to construct large archived environmental DNA (eDNA) libraries, thousands of genomes from both cultured and as yet uncultured bacteria can be simultaneously screened for gene clusters encoding natural products of interest. Several natural products with pharmaceutically relevant biological …
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The Application of Functional Metagenomics to Natural Products Research
… encoded on fragments of environmental DNA (eDNA) as evidenced by the expression of these traits in model cultured bacterial hosts. Functional metagenomic techniques can be tailored towards finding metagenome-derived small molecule biosynthetic capabilities, thereby allowing access to novel …
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Novel Molecules from Environmental DNA-Derived Type II Polyketide Biosynthetic Gene Clusters
… approach of extracting environmental DNA (eDNA) from soil and cloning it into a library was leveraged to take advantage of the genetic diversity of uncultured microbes. Uncultured microbes have been found to be rich in type II polyketide synthase (PKS) gene clusters (Kieser, Bibb et al. …