Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1007 for “"dysregulation"”.
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Cytokine Dysregulation Promotes HPV Persistence
… represents a novel explanation for cytokine dysregulation associated with HPV carcinogenesis.</p>
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Ionic dysregulation in white matter damage
… significantly to impairment of brain function. Dysregulation of ion gradients across membranes is a common phenomenon across many diseases and can be damaging due to increased metabolic demand, oedema and activation of destructive enzyme cascades. Breakdown of ionic gradients can occur under …
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Iron Dysregulation and Inflammation in Alzheimer’s Disease
… of AD and other forms of neurodegeneration, iron dysregulation and inflammation, both of which can promote the increased production of amyloid precursor protein (APP). We have measured different pools of brain iron in transgenic iron regulatory protein 2 knockout (IRP2-/-) mice in the early stages …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… identified transcriptomic and proteomic dysregulations in neuropsychiatric disorders, and motivations for the work presented in the thesis are introduced in Chapter 1. In Chapter 2, we evaluated sex-stratified cell count corrected case-control differences in gene expression and (where …
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Epigenetic dysregulation of novel candidate genes in melanoma
… summary, my study proposes that epigenetic dysregulation by CpG island methylation of tumour-related genes TFPI2, P4HA3, NT5E and DUSP2 is important in melanoma development and progression and that detection of methylated DNA from these genes may provide novel biomarkers for predicting …
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MicroRNA Dysregulation in Neuropsychiatric Disorders and Cognitive Dysfunction
… expression. Genetic Variants may cause microRNA dysregulation and the concomitant aberrant target expression. The dysregulation of one or a few targets may in turn lead to functional consequences ranging from phenotypic variations to disease conditions. In this thesis, I present our studies of …
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Dysregulation of connexin-43 (cx43) in doxorubicin-induced cardiotoxicity
The chemotherapeutic drug doxorubicin (DOX) is widely used in the treatment of cancer; however patients experience dose-dependent cardiotoxicity that can manifest acute, early- and late-onset chronic and is associated with a decreased contractility and dilated cardiomyopathy. Similar effects have …
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DIABETES MELLITUS AND THE DYSREGULATION OF ANGIOGENESIS IN TUBERCULOSIS
Diabetes mellitus (DM), characterized by chronic hyperglycemia, is a risk factor for tuberculosis (TB), contributing to more severe disease and poorer treatment outcomes. Angiogenesis plays a key role in TB immunopathology by supporting mycobacterial survival within granulomas, whereas …
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AMD, analysis of mood dysregulation : a machine learning approach
… with repeated exposures to psychological mood dysregulation, which can lead to or worsen stress related conditions such as heart disease and cancer. Therefore, mobile ambulatory assessment systems are actively being developed for various psychological studies. However, to the best of our …
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Dysregulation in polycystic ovary syndrome: mechanisms and therapeutic approaches
Polycystic ovary syndrome (PCOS),a complex widespread hormonal disorder that affects between 8-13% of reproductive-aged women globally. It is marked by high levels of androgens (male hormones), irregular ovulation, and metabolic disorders, all of which are linked to disruptions in gonadotropin …
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From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
The maintenance of a continuous flow of mature blood cells from a reservoir of specialised haematopoietic stem cells requires regulation from an intricate network of regulatory programmes. Gene regulatory networks are well evolved to control multi-lineage commitment and differentiation while …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
Regulation of host health is intricately coordinated by a diverse interplay of immune cells detecting assaults from pathogens via recognition of pathogen associated molecular patterns (PAMPs) to mount an immune response, as well as detecting damage associated molecular patterns (DAMP) to indicate …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… Overall, we have pursued four main aims; Aim 1. Dysregulation of mitochondrial quality control machinery leads to cardiac death; Aim 2. HIV-1 Tat (transcriptional transactivator) dysregulates cardiac homeostasis via mitochondrial pathway; Aim 3. Impairment of protein quality control impacts the …
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DYSREGULATION OF AMP-ACTIVATED PROTEIN KINASE SIGNALING IN ALZHEIMER’S DISEASE
The etiology of Alzheimer’s disease (AD), one of the most grievous neurodegenerative disease, is still unclear despite decades of study and early diagnosis of this disease remains a challenge. Energy metabolic dysfunction has been found to be a distinct characteristic in Alzheimer’s disease, and …
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RNA Dysregulation in a Novel Human Model of TDP43 Proteinopathy
… including dendritic defects, apoptosis, microRNA dysregulation, as well as hyperphosphorylation and, likely, aggregation of TDP43. Simultaneously, the nuclear loss of TDP43 results in widespread alternative splicing errors. In a doxycycline-inducible version of this model, we demonstrate that …
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
Individuals at risk for developing Alzheimer's disease (AD) often exhibit neuronal network hyperexcitability, particularly in the CA3 region of the hippocampus, in the years preceding AD diagnosis, suggesting that aberrant network activity might contribute to the pathogenesis of AD. Recently, the …
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Emotion Dysregulation and the Interpersonal Theory of Suicide in Adolescents
… in the current literature. First, emotional dysregulation has been consistently linked to suicide attempts, and appears to have a complex relationship with IPTS constructs in adults, but has been under-investigated in clinical adolescents when it may have particular relevance to suicidality. …
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Cellular and Organismal Ramifications of de novo Purine Synthesis Dysregulation
… identified influenced by <em>de novo</em>purine dysregulation identified are focused around neural, embryonic, organ, and placental development, epithelial to mesenchymal transition, fatty acid and inflammatory response, muscle function, tumorigenesis, oxidative stress responses, as well as …
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Investigating dysregulation in protein quality control mechanisms in senescent cells
Loss of proteostasis and cellular senescence are both considered major hallmarks of ageing, and contribute to the development and maintenance of diseases of ageing. Cellular senescence enacts a programme of stable cell-cycle arrest, accompanied by profound alterations in cellular function including …
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