Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"dysregulated gene"”.
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The design, characterization, and application of CRISPR-based tool in human cells
Many human diseases are associated with dysregulated gene expression. A subset of these diseases arise from deviated functional protein expression from homeostatic regimes. Either not enough, or too much, functional protein expression can cause toxic accumulation of metabolites, dysregulate …
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Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
… GFP expression under the control of one such dysregulated gene (Drd2), I have improved on previous protocols for the isolation and characterization of adult neurons by flow cytometry. Drd2 is a well-studied marker of a particularly vulnerable population in HD patients, the indirect medium …
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Disturbo bipolare e cefalea a grappolo: identificazione di geni e pathway molecolari e loro potenziale coinvolgimento nella risposta alla terapia con sali di litio tramite analisi dei profili di espressione genome‐wide
… conditions affecting 1% and 1.5% of the general population, respectively. Albeit the pathogenesis has not yet been completely elucidated, family and twin studies have suggested a genetic basis for both disorders, with an estimated heritability of 80% for BD and up to 60% for CH. Though BD …
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AGGREGATION MECHANISMS OF TDP-43 PROTEIN IN RESPONSE TO STRESS IN AMYOTROPHIC LATERAL SCLEROSIS AND THERAPEUTIC APPROACHES
… Lateral Sclerosis (ALS) is a rare neurodegenerative disorder affecting upper and/or lower motor neurons for which no effective cure is available to date. The neuropathological hallmark of the disease, present in 97% of ALS cases, consists in TDP- 43 proteinopathy characterized by the …
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ADAMTS1 is a promoter of metastatic cell behaviour in mammary cancer cells.
… and upregulation of the endogenous ADAMTS1 gene have been strongly associated with metastatic disease in breast cancer. The MMTV-PyMT transgenic breast cancer model recapitulates in vivo metastasis and ablation of Adamts1 impeded the aggressive advancement and growth of pulmonary metastases. …
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A novel route to oncogenic activation of cell cycle kinase Aurora A
… are normally in place at different steps of gene expression to ensure that AURKA levels are tightly fine-tuned during each phase of the cell cycle. A prominent association exists between high expression of AURKA and cancer, and AURKA gene is classifiable as oncogene. AURKA is indeed a highly …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… Questi geni Over-UpT sono arricchiti di "Fitness Genes", molti dei quali coinvolti nell’inizio della traduzione e nella poliadenilazione dell'mRNA. In questa tesi, sono stati analizzati i profili genomici e trascrittomici dei geni correlati ai pathway Fitness-OverT, tra cui eIF2, eIF3, CSTF e …