Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"dysmyelination"”.
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
… cerebellar atrophy, defect of Purkinje cell and dysmyelination in the brain. In the case of dysmyelination, this is a subset of white matter disorders characterized by differentiation defect of oligodendrocytes, also known as leukodystrophy. We found that neurons and astrocytes in the …
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Stressed Astrocytes: Insights on the Pathology of Alexander Disease
… is astrocytic, AxD patients also show de/dysmyelination and variable amounts of neuronal loss, most severely in infantile-onset patients. Astrocytes undergo severe morphological changes, beyond that of typical reactive astrocytes, and develop several forms of cell stress. However, how …
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The effects of increased Plp1 gene dosage on expression and processing of myelin proteins
… increased Plp1 gene dosage. The cause of the dysmyelination observed in #66 mice and patients with PMD does not appear to be due to one single change in myelinogenesis. Each alteration observed in #66 transgenic mice could be a contributing factor. Importantly, the perturbation of MBP …
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Transgenic complementation of rumpshaker with wild type proteolipid protein
… 1992) generates a misfolded protein resulting in dysmyelination and increased numbers of apoptotic oligodendrocytes. The phenotype varies from mild on the original C3H background to lethal when backcrossed onto the C57BL/6 mouse strain (Al-Saktawi et al., 2003). Utilising the more severe variant …
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DTI-based tractographic analysis of white matter alterations in HIV infected children
… in HIV+ children point to demyelination/dysmyelination within six networks. Four of these networks – the basal ganglia, default mode, salience and somatosensory – were all found to have altered functional connectivity in a previous study; therefore, these results point to damage or …
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Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease
… cause axonal injury and significant early-onset dysmyelination and late-onset demyelination. The exact mutational mechanism remains to be described, although substantial progress had been made to make reasonable assessments that may provide a better understanding towards the disease pathogenesis. …
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Charakterisierung der subzellulären Lokalisation von Myelinproteinen in der Shiverer-Maus.
Wie demyelinisierende Erkrankungen bei Mensch und Tier zeigen, erfüllt Myelin als Isolierscheide der Nervenfasern lebenswichtige Funktionen. Es handelt sich um eine Membran sehr spezifischer Zusammensetzung, deren Komponenten in komplexer Wechselwirkung mit einander stehen. Die vorliegende Arbeit …