Global ETD Search
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Showing 1 to 2 of 2 for “"dysiherbaine"”.
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A general scaffold for the synthesis of cysiherbaine and its analogues
Dysiherbaine 1 and a select number of structurally related compounds have been shown to have selective effects on ionotropic glutamate receptors (iGluRs). iGluRs are essential components in the central nervous system (CNS); playing an important role in memory and learning. They also play a role in …
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A structure-function analysis of the marine toxin neodysiherbaine and its synthetic analogs on kainate receptors
… of affinity and activity of the marine toxin dysiherbaine, DH. DH is a high-affinity kainate receptor agonist and the most potent convulsant excitatory amino acid identified to date. The structure of DH is unique relative to other kainate receptor agonists because it has a glutamate backbone …