Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"dysgenesis"”.
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Gonadal dysgenesis and hermaphroditism
… a study of a series of patients with a gonadal dysgenesis. Shortly after the inception of the study, Pelani and his co-workers (1954) published a report on the nuclear chromatin pattern in three cases of the syndrome. Their findings provided one of the most illuminating contributions made in the …
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Role of androgens in testicular development and dysgenesis
… they are hypothesized to comprise a testicular dysgenesis syndrome (TDS). TDS arises when maldevelopment (dysgenesis) of the fetal testis results in hormonal malfunctions and abnormal development and function of the somatic cells. It is thought that the suppressed intratesticular testosterone …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… epithelium recapitulated the fetal testis cord dysgenesis present in Inhba-/- mice, indicating the Sertoli cells are likely the direct targets of activin A signaling. I have thus identified a novel mesenchymal-epithelial crosstalk in the developing testes wherein interstitial fetal Leydig cells …
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When good synapses go bad: dendritic spine dysgenesis in a mouse model of Fragile X mental retardation
… and interesting is a pattern of dendritic spine “dysgenesis”, found in patients and animal models of the disorder. Specifically, dendritic spines, thorn-like protrusions associated with synapses, appear “immature”: often exhibiting abnormal length and shape, and found in higher than typical …
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Understanding Host Tolerance to Transposable Elements
… advantage of a unique phenomenon called hybrid dysgenesis in Drosophila melanogaster where naïve females devoid of P-element DNA transposon typically produce sterile offspring when mated with P-element carrying males. However, tolerant individuals are capable of producing viable gametes in spite …
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Reproductive health effects due to pesticide exposure amongst boys in the rural Western Cape, South Africa
… cancer and poor sperm quality (testicular dysgenesis syndrome) have also been reported to be associated with these endocrine-disrupting chemicals. This study therefore aims to investigate the adverse reproductive health effects of environmental pesticide exposure in male children and …
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Protein Contributions of the Male Accessory Organs to the Composition of Human Seminal Plasma as Determined by High Resolution Two-Dimensional Electrophoresis
… fertility disorders (i.e. reproductive organ dysgenesis or dysfunction), patients who have undergone surgical procedures (varicocele repair, vasectomy, trans-urethral resection etc.), or specimens from patients who have produced secretions as a result of prostatic or seminal vesicle massage in …
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Responses to transposon activity and genome damage during germline development
… sterility in Drosophila, P-M hybrid dysgenesis, as a model. I show that excessive activity of the P-element transposon in embryonic primordial germ cells (PGCs) leads to the accumulation of DNA double strand breaks (DSBs) and sustained cell cycle arrest prior to fully penetrant germ …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… such as ventriculomegaly and corpus callosum dysgenesis, suggesting a possible role in the context of neocortical development. My PhD project explored their effect on progenitors’ morphology, proliferation and neuronal outcome, providing further insights into the mechanisms that regulate brain …
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Antiandrogens and Development of the Male Rat Reproductive Tract
… seminiferous tubules was identified. Testicular dysgenesis was observed with a similar incidence between age groups in mature rats, which supports in utero induction by DBP rather than development over time. Together these data provide insight into the molecular mechanisms underlying the …
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
… identified association of BMP7 with testicular dysgenesis syndrome; however the molecular mechanisms behind this association remain unknown. Previously, we described the development of testicular germ cell tumors in zebrafish carrying a mutation in bmpr1bb, a BMP family receptor, and …
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Analysis of the Function of Megf7 During Development
… and is involved in a natural form of limb dysgenesis. This work will serve as the groundwork for future analysis of Megf7.
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… neurofibromatosis type 1 syndrome, caused lens dysgenesis in mouse. While early lens specification proceeded normally in Nf1 mutants, lens induction was disrupted due to deficient cell proliferation. Further analysis showed that ERK signaling was initially elevated in invaginating lens placode, …
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Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus
… childhood, characterized by renal cysts, biliary dysgenesis and congenital hepatic fibrosis due to ductal plate malformation. With an estimated incidence of 1 in 20,000 up to 50% of the affected neonates die shortly after birth. ARPKD is caused by mutations in a single gene (Pkhd1, polycystic …
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The impact of genetic, environmental and life-style factors on male reproductive function
… cause and are symptoms of a so called Testicular Dysgenesis Syndrome (TDS). The aetiology of TDS is unknown but genetic, environmental and life-style related factors have been suggested as its causes. Genetic factors might, at least partly, explain the difference in male reproductive function …
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Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
… of the gland, collectively named thyroid dysgenesis. The disease results from defective thyroid organogenesis during embryonic life. However, the molecular mechanisms of pathogenesis are largely unknown. In recent years, identification and functional analysis of thyroid developmental genes …
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Synaptic morphology, function, and regulation in a paediatric-onset neurodegenerative disorder
… mechanisms contributing to dendritic spine dysgenesis/loss. 4. Determine if synaptic degeneration can be prevented by administering AAV9-based gene therapy prior to symptom-onset. The hypothesis was that changes in synaptic morphology and function underlie cognitive decline in MPS IIIA. The …
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Retrospective review of women diagnosed with premature ovarian insufficiency
… patients with primary amenorrhoea 4 had gonadal dysgenesis. After completing investigations, the cause was not identified in 36.3% (n=110) of the patients, followed by genetic causes 20.8% (n=63), chemo/RT 9.6% (n=29), iatrogenic 5.0% (n=15) and autoimmune causes 4.6% (n=14). Investigations were …
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Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… connectivity, particularly dendritic spine dysgenesis. There is also an emerging view that aberrant local protein synthesis within dendrites and protein trafficking to dendrites underlies some forms of MR (Kelleher and Bear, 2008; Pfeiffer and Huber, 2006; Zalfa and Bagni, 2005). Most …
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