Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"dynorphin"”.
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Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
… drug addiction. During a stressful event, the dynorphins, a family of endogenous opioids, are released and subsequently bind to and active the kappa opioid receptor (KOR), but how the dynorphin/KOR system mediates these adverse behaviors remains unknown. My dissertation sought to further our …
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
… and their endogenous neuropeptide ligands (dynorphin, endorphin and enkephalin, respectively), mediates mood and reward. Activation of the mu opioid receptor is associated with positive reward and euphoria, while activation of the kappa opioid receptor (KOR) has the opposite effect. …
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The Role of Neurokinin B in the Regulation of the Preovulatory LH Surge in Ewes
… two other neuropeptides as well: NKB and dynorphin A (DYN). Thus, these neurons were assigned the acronym KNDy neurons. The specific role of these two kisspeptin-containing populations in GnRH/LH regulation is unclear. Therefore we examined the degree to which each of these populations …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. We found that conditional deletion of KOR from Slc6a4 …
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Early Diagnosis of Alzheimer's Disease and Studying Binding to Opioid Receptors using Whispering Gallery Mode Microtoroid Biosensors
… to study interactions with its agonist, the Dynorphin A molecule. In the body, the KOR regulates pain, stress, and mood, and are a potential target for novel pharmaceutical drugs as an alternative for pain management with lower potential for addiction than other opioid receptors. Lastly, …
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… of the amygdala, whereas leucine-enkephalin, dynorphin and neurotensin increased ipsilaterally in the central nucleus of the amygdala. Sham MCAO was ineffective.;Neurochemical changes were assessed 5 days after localized excitotoxic lesion of the IC or primary somatosensory cortex (SSC-I). …
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The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
… and glutamate pathways in the enkephalin and dynorphin positive neurons of AcSh. This work identifies a novel hypothalamic-AcSh circuit that may integrate the homeostatic and hedonic aspects of feeding. Together, these studies identify new roles for LH peptides in drug addiction, feeding and …
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The role of the kappa opioid receptor system in forebrain dependent associative learning
… a significant increase in the amount of the dynorphin precursor peptide prodynorphin (PD) in the somatosensory cortex during and immediately following WTEB training. Collectively, the findings presented in this dissertation outline a novel role for KOR in the acquisition and consolidation of …
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
Acid-sensing ion channels (ASICs) are proton-gated channels expressed in neurons in the central and peripheral nervous systems. These ion channels are sensors for extracellular pH and contribute to a variety of normal functions including learning and memory, seizure termination, fear, anxiety, and …