Global ETD Search
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Showing 1 to 2 of 2 for “"dynapyrazole"”.
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Chemical Biology of Dynein
… domain have been reported, such as ciliobrevins, dynapyrazoles and dynarrestin, but the inhibitor-binding site(s) have yet to be elucidated. Though inhibitor-bound dynein structures have been long-sought after, efforts have been curtailed by difficulties in obtaining high-resolution dynein …
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Chemical Approaches to Dynein Inhibition
… chapter, "Chemical structure-guided design of dynapyrazoles, cellpermeable dynein inhibitors with a unique mode of action," I present a rational approach to the development of derivatives of ciliobrevins that have improved potency and several improved chemical properties relative to the …