Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"dynamic force spectroscopy"”.
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Theoretical and computational modeling of peptide-lipid bilayer interaction studied by dynamic force spectroscopy
… the quantitative description of the detachment force distribution, P(F), and the corresponding force dependent detachment rate, k(F), of a peptide from a lipid bilayer, by assuming that peptide detachment from lipid membranes occurs stochastically along a few dominant diffusive pathways. Besides …
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Molecular Basis of Cell Adhesion Mechanics
… multiple adhesion bonds in parallel subject to dynamic forces. Correlations between the dynamic strength and measurable kinetic and thermodynamic properties of the molecular bond are predicted based on the model. The model is further extended to a sphere-on-plane geometry commonly used in …
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Methods of single-molecule energy landscape reconstruction with optical traps
Optical traps facilitate measurement of force and position as single molecules of DNA, RNA, or protein are unfolded and refolded. The effective energy landscape of a biomolecule can be reconstructed from the force and position data, providing insight into its structure and regulatory functions. We …
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Study of T cell activation and migration at the single-cell and single-molecule level
… sites, a journey that exposes them to distorting forces and physical obstacles that hinder their movement. Therefore, they must possess appropriate deformability to accommodate and adapt to these mechanical stimuli to migrate unimpeded. Since T cells alter their physical properties and migration …
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Force and Conductance Spectroscopy of Single Molecule Junctions
… that enables the statistical evaluation of force and simultaneous conductance data of metallic atomic point contacts and molecular junctions. A conductive atomic force microscope based break junction technique is developed to form single molecular junctions and collect conductance and force …
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Probing static disorder in protein unfolding and chemical reactions by single-molecule force spectroscopy
… of biomolecular reactions under mechanical force, including protein unfolding and disulfide-bond reduction, probed at the single-molecule level. The advent of single-molecule force spectroscopy has allowed the direct measure of force-dependent reaction rates, providing a powerful approach to …
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Investigation of biological macromolecules using atomic force microscope-based techniques
The atomic force microscope (AFM) provides a powerful instrument for investigating and manipulating biological samples down to the subnanometer scale. In contrast to other microscopy methods, AFM does not require labeling, staining, nor fixation of samples and allows the specimen to be fully …
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Stochastic dynamics of adhesion clusters under force
… adhesion sites are usually subject to physical forces. In recent years, the influence of such forces on the stability of cellular adhesion clusters was increasingly investigated. In particular, experimental methods that were originally designed for the investigation of single bond rupture under …