Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"dynamic clamp"”.
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Effect of Background Synaptic Activity on Excitatory-Postsynaptic Potential-Spike Coupling
… vivo</em> synaptic activity of the cell with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices<em> in vitro</em> to investigate how timing and probability of spike generation in response to an EPSP is affected by background synaptic conductance under these …
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
… somatic ion channels under ideal voltage-clamp conditions, I started to examine the functional properties of Kv channels expressed in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic inhibitory interneuron. The main results are as follows. First, the …
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Impact of Noise and Spike Initiation Properties on the Encoding and Transmission of Neural Information
… spike-based representations. Using patch clamp electrophysiology combined with optogenetics, I showed that the axon of CA1 pyramidal neurons spikes transiently in response to sustained depolarization, in contrast to the soma and axon initial segment, which spike repetitively. These …
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A mathematical and computational exploration of the effect of the A-current in determining the activity phase of follower neurons
… components. In the first component, methods of dynamical systems are applied to explore the transient properties of the activity phase of the follower neuron, which is modeled using a simplified three-variable model based on the Morris-Lecar equations. Based on the analysis of the effect of the …
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Determining how stable network oscillations arise from neuronal and synaptic mechanisms
… properties of isolated neurons or through the dynamics of their synaptic connections or both. A combination of pharmacological and electrophysiological techniques a used to show how identified membrane properties and short-term synaptic plasticity are involved with phase maintenance over a …