Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"ductal cells"”.
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The mesenchymal regulation of ductal-driven liver regeneration
Liver epithelial cells –hepatocytes and bile duct cells– intermingle with a microenvironment of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become …
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Long-term expansion, genomic stability, in vivo safety and immunogenicity of adult human pancreas organoids
… described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously reported human pancreas organoid (hPO) cultures do not expand efficiently long-term in a chemically defined, serum-free medium. The …
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The role of Arid1a and Tet1 in ductal cell-driven liver regeneration
Title: The role of Arid1a and Tet1 in ductal cell-driven regeneration Author: Mikel Alexander Mckie The liver has several robust and potent mechanisms of repair after damage despite slow homeostatic turnover. In cases of extreme toxic damage, where the hepatocyte compartment is severely compromised …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… <p><strong> </strong></p> <p>Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer in the world. The most common genetic lesions identified in PDAC include activation of K-ras (90%) and Her2 (70%), loss of p16 (95%) and p14 (40%), inactivation p53 (50-75%) and Smad4 (55%). …
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Studies on intracellular calcium pools in a pancreatic cell line
… the only intracellular Ca²⁺ mediator. In some cells, guanosine 5'-triphosphate (GTP) and arachidonic acid are known to mobilize intracellular Ca²⁺ independent of the action of IP₃ and probably play important roles in Ca²⁺ signalling. In pancreatic ductal cells the precise mechanisms of …
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Consequences of Plk4 overexpression in mouse pancreatic organoids
… proliferation of pancreatic endocrine α-cells and β-cells. This project aimed to investigate the consequences of Plk4 overexpression on pancreas cell biology using mouse pancreatic ductal organoids. In accord with previous observations, immunofluorescence experiments confirmed that Plk4 …
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
<p> <p> Pancreatic ductal adenocarcinoma (PDAC) represents the fourth most common cause of cancer-associated death in the United States. Little progress has been made in understanding how proteotoxic stress affects rapidly proliferating pancreatic tumor cells. Endoplasmic reticulum (ER) stress …
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INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
… common in the extracellular matrix on epithelial cells is present in the pancreas, lining the duct lumen. During pathological conditions, we propose that it can be shed from the ECM and bind to receptors on the cell surface, thus triggering an inflammatory response, which if excessive can cause …
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Investigating the role of macrophage-epithelial cell interaction in salivary gland regeneration
… that CX3CR1+ macrophages home specifically to ductal cells following radiation injury, and that DNA damage is more severe upon the genetic depletion of macrophages compared to radiation alone. In addition, via in vivo analysis and a novel method for ex vivo live imaging, I show that macrophages …
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Acute pancreatitis, from local defense to remote organ injury
… of extracellular matrix which lines the ductal cells in the pancreas. During the process of the disease, active enzymes in the pancreas will cause shedding of HS. We have shown that HS is able to start an inflammatory response in the pancreas. This response was mediated via Toll like …
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Transcriptomic analysis of pancreatic cells in zebrafish
… the metabolism of all vertebrates. The endocrine cells are mainly grouped into the islets of Langerhans and secrete distinct hormones, such as glucagon (α-cell), insulin (β-cell), somatostatin (δ-cell) and ghrelin (ε-cell). Diabetes occurs when insulin production by the β-cells is unable to …