Global ETD Search
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Showing 1 to 6 of 6 for “"dsDNA virus"”.
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Mechanisms of Adenovirus Membrane Permeabilization
<p>For a successful infection to occur, a virus must first penetrate host cell membranes to access intracellular sites of viral replication. Currently the mechanism through which adenovirus, a non-enveloped, dsDNA virus, disrupts the endosomal membrane during cell entry is not well …
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Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
<p>Adenovirus (Ad), a non-enveloped, dsDNA virus, enters cells via clathrin-mediated endocytosis. For viral genome delivery to the nucleus, Ad must penetrate endosomal membranes to create defects sufficient for the passage of the 90 nm diameter capsid across cell membranes. Recent observations …
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Structure and Function Study of Phi29 DNA packaging motor
<p>A powerful nanomotor is employed by the tailed dsDNA virus to package the genome into a preformed protein shell during the process of replication. The bacteriophage phi29 is an excellent model for investigating the viral DNA packaging mechanism. The phi29 DNA packaging motor is composed of three …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
BK polyomavirus (BKPyV) is a small, non-enveloped dsDNA virus that infects 70 – 90% of the world’s population and causes a lifelong, silently persistent infection. In immunocompromised individuals, BKPyV replication can result in serious pathology. Bone marrow transplant patients can develop …
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An exploration of the interplay between HSV-1 and the non-homologous end joining proteins PAXX and DNA-PKcs
… (NHEJ) is a mechanism of double stranded DNA (dsDNA) repair that functions to rapidly mend broken DNA ends. The NHEJ machinery is well characterised in the context of DDR but recent studies have linked the same proteins to innate immune DNA sensing and, hence, anti-viral responses. The aim of …
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An investigation into BK Polyomavirus and host-virus interactions
… potentially oncogenic human pathogen BK Polyomavirus (BKPyV) was first identified in 1971 and has since been associated with a number of diseases primarily in immunosuppressed patients. Infection is established in early life and by adulthood up to 90% of populations show seroconversion for the …