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Showing 1 to 13 of 13 for “"dry powder inhaler"”.
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Development of dry powder Inhaler and nebulised nanoparticles formulations of chrysin for the potential treatment of asthma. Development of dry powder inhaler of chrysin and nebulised nanoemulsion combination of chrysin and budesonide; Evaluating the anti-inflammatory activity of the combination formulation of chrysin and budesonide for asthma
… combined formulations of chrysin and budesonide. Dry powder inhaler formulations were used first, where chrysin was processed using three different techniques, namely ball-milling, sonocrystallisation, and spray drying, to obtain a suitable particle size for inhalation. The highest fine particle …
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Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
Curcuminoids have strong anticancer activities but have low bioavailability. The highest rate of cancer deaths comes from lung tumours; therefore, inhaled curcuminoids could treat lung cancer locally. To date, there are no nebulised formulations of curcuminoids, and there are no inhalable …
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Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.
… energetics play a key role in the delivery of a dry powder inhaler formulation into the lungs, as there must be a sufficient balance of adhesive and cohesive forces to allow optimal lung delivery. In this study, measuring the surface energies of a set of single drug and carrier (budesonide or …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… formulation that could be delivered via dry powder inhaler for use in chronic lung infection. By delivering the antibiotic directly to the site of action in the lungs, higher local concentrations could be achieved whilst overcoming issues with oral therapy such as systemic side effects …
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Manipulation of carrier particles for inhalation
… of these materials as drug carriers in a dry powder inhaler (OPI). The main aim of the research was to establish whether a relationship exists between the surface characteristics of a material and the performance of the material as a drug carrier in a OP!. A fundamental part of the …
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Novel Technology for Crystal Engineering of Pharmaceutical Solids
… particles for pulmonary drug delivery system via dry powder inhaler (Foradil inhaler). The results demonstrate that the THF particles generated using MASCW process displayed greater aerodynamic performance compared to conventional spray-dried THF sample. In the final chapter, synthesis of …
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Evaluation of novel tool to ensure asthma and COPD patients use the approved inhalation technique when they use an inhaler. Clinical pharmacy studies investigating the impact of novel inhalation technique training devices and spacers on the inspiratory characteristics, disease control and quality of life of patients when using their inhalers.
Many respiratory patients misuse their inhaler. Although training improves their inhaler technique, patients do forget the correct inhaler use with time. In the current work, three clinical studies investigated novel tools designed with feedback mechanisms to ensure patients use the correct …
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Computational Modelling and Optimization of Dry Powder Inhalers
Dry powder inhalers (DPIs) are a common therapeutic modality for lung diseases such as asthma, but they are also used to treat systemic diseases such as diabetes. Advantages of DPIs include their portable design and low manufacturing costs. Another advantage of DPIs is their breath activation, …
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Relative bioavailability of terbutaline to the lungs following inhalation using different methods.
… in-vitro characteristics of terbutaline sulphate inhalers were measured according to standard compendial methodology as well as adaptation of this methodology to simulate routine patient use. The dose emission of terbutaline sulphate from a Bricanyl Turbuhaler was determined using an inhalation …
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
Powder flow is an integral component in pharmaceutical manufacturing. Various powder flow methodologies were examined and correlated with each other using lactose of various shape and size. In-die powder flow during tableting was studied using lactose particles of different surface roughness. …
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Characterization of Drug-Loaded Milled Extrudate Particles Produced by Hot Melt Extrusion Technology for Dry Powder Inhalers
… investigation is to develop a sustained-release dry powder inhalation (DPI) formulation through continuous Hot Melt Extrusion (HME) process and see the impact of Sodium Bicarbonate (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were …
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Particle Engineering via Spray Freeze-Drying for Pulmonary Drug Delivery Applications
L'abstract è presente nell'allegato / the abstract is in the attachment
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In vitro methods to predict aerosol drug deposition in normal adults
… of predicting in vivo drug deposition from dry powder inhalers, DPIs, in lung-normal human adults. Three physical models of the mouth, throat and upper airways, MT-TB, were designed and validated using the anatomical literature. Small, medium and large versions were constructed to cover …