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Showing 1 to 8 of 8 for “"dry granulation"”.
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Novel Application of Twin Screw Extruder on Production of Diverse Formulations
… nanocrystal formulations, such as spray drying and freeze-drying, have some drawbacks, including high cost, time and energy inefficiency, traces of residual solvent. In this study, twin-screw extruder was combined with high pressure homogenizer to successfully produce nanocrystal solid …
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The Effect of Crystalline and Amorphous Lactose on Mechanical Properties of Roller Compaction Ribbons and Tablets
… is infrequently used in large concentrations for dry granulation processes because alpha-lactose monohydrate exhibits relatively poor binding properties and consolidates mainly by fragmentation due to its `brittleness'. Though this is true of crystalline lactose, previous direct compaction …
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The impact of stress history of deformable dry granules on the mechanical properties of tablets
… development of a quality tablet. However, in the dry granulation literature, milled granules that are polydisperse in solid fraction, size, and shape are extensively used for compaction studies. Thus, the effect of an individual granule property or an individual component on the compaction …
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… work evaluated the use of roller compaction as granulation method for hydroxypropyl methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and pressed …
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Hot-melt extrusion: A versatile pharmaceutical technology
… critical quality attributes (CQAs) to develop a dry-granulation process for controlled release formulation of OND SR tablets by twin-screw extruder. The effect of screw speed, feed rate and amount of fumaric acid on the particle size and flow properties of the granules and time required for …
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Characterisation of Tablets and Roller-Compacted Ribbons with Terahertz Time-Domain Pulsed Imaging
The pharmaceutical process of dry granulation using roller-compaction (DG/RC) is effectively a non-batch based procedure orientated to deliver a continuous stream of material free of a pre-defined batch-size with reduced plant equipment/scale-up R&D resources and an enhanced work-throughput, …
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Crystallization of Synthetic Blast Furnace Slags Pertaining to Heat Recovery
Heat recovery from blast furnace slags is often contradicted by another requirement, to generate amorphous slag for its use in cement production. As both the rate and extent of heat recovery and slag structure are determined by its cooling rate, a relation between the crystallization kinetics and …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… direct compression as well as spray, wet and dry granulation. The effect of the ratio of the two components, percentage of lubricant and particle size on the properties of the prepared co-processed excipient has been investigated. -Chitin forms non-hygroscopic, highly compactable, …