Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"drug-resistant epilepsy"”.
-
Time-resolved Resting-state fMRI of Brain States Associated with Drug-resistant Epilepsy
… of aberrant activity in individuals with drug-resistant epilepsy. Specifically, a dynamic functional connectivity analysis method is first used to determine the temporal dynamics of brain activity, followed by two unsupervised machine learning algorithms, k-means and hierarchical …
-
Paediatric epilepsy surgery in a middle-income country: the red cross war memorial children's hospital experience
Purpose While epilepsy surgery has been shown to reduce seizure frequency and severity and even cures seizures in children with drug-resistant epilepsy, data from middle-income countries (MIC) are lacking. Method This study is a retrospective review of children with drug-resistant epilepsy who …
-
Development and Characterization of Pre-Clinical Epilepsy Models to Evaluate Potential Anti-Seizure Targets.
Epilepsy is the oldest known neurological disorder in humans and has been extensively studied for decades. Nevertheless ~30% epilepsy patients remain refractory to pharmacological intervention today. Limitations of animal models that are used in anti-epileptic drug screening, and a lack of novel …
-
Clinical Cost-Effectiveness as a Novel Metric for Steering Emerging Medical Technology
… making decisions under uncertainty. Localized drug delivery (LDD) is an emerging medical technology that may be useful in treating epilepsy, which is burdensome and difficult to clinically manage. Costeffectiveness analysis (CEA) is a model-based, problem-oriented framework for determining …
-
UNSUPERVISED CLASSIFICATION OF HIGH-FREQUENCY OSCILLATIONS IN NEOCORTICAL EPILEPSY AND CONTROL PATIENTS
… of life for the more than 15 million people with drug-resistant epilepsy is tied to how precisely the brain areas responsible for generating their seizures can be localized. High-frequency (100-500 Hz) field-potential oscillations (HFOs) are emerging as a candidate biomarker for epileptogenic …
-
A molecular approach to precision medicine in South African children with Epilepsy: towards a genetics-based diagnostic service for Epilepsy
Background: Epilepsy is a neurological disorder characterised by unprovoked, recurring seizures. SubSaharan Africa carries the highest burden of epilepsy in the world, owing mainly to the increased risk factors such as infectious and parasitic disease, and traumatic brain injury. A proportion of …
-
Characterizing the Developmental and Reproductive Toxicities of Cannabidiol and Δ9-Tetrahydrocannabinol
… legislation for cannabidiol (CBD) treatment of drug-resistant epilepsy, such as Dravet Syndrome (DS) which is diagnosed in children as young as two months. While CBD has shown anecdotal and recently clinical trial efficacy in reducing seizure frequency in DS patients, little is known about the …
-
Observational and Experimental Studies on the Diagnosis and Outcome of Epilepsy and Epileptogenic Conditions: Investigating the Static and Dynamic Phenotype of Epilepsy
… been performed to investigate the spectrum of epilepsy. The topics were: 1. The differential diagnosis between epilepsy and another common clinical condition (PNES); 2. The verification if epilepsy could be a marker of genetic diseases characterized by intellectual disability and behavioural …
-
Quantitative MRI correlates of hippocampal and neocortical pathology in intractable temporal lobe epilepsy
Intractable or drug-resistant epilepsy occurs in over 30% of epilepsy patients, with many of these patients undergoing surgical excision of the affected brain region to achieve seizure control. Advances in MRI have the potential to improve surgical treatment of epilepsy through improved …
-
Computational Approaches To Epilepsy: Graph Networks For Localization And Multi-Model Approach For Prediction
Epilepsy is one of the world's most common neurological diseases, affecting over 50 million people. Nearly a third of these individuals have drug-resistant epilepsy (DRE), a condition characterized by a lack of response to antiseizure medications. For these individuals, the primary remaining …
-
EXPLORING PHYSIOLOGICAL, PATHOLOGICAL AND PARAPHYSIOLOGICAL BRAIN ACTIVITY ACROSS SCALES WITH SIMULTANEOUS INVASIVE AND NON-INVASIVE EEG
… foci, which is critical for surgical planning in drug-resistant epilepsy cases. Second, the study investigates physiological brain responses to sensory stimuli using median nerve stimulation. Co-registration enabled the analysis of how brain signals propagate from primary sensory regions to …
-
CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY
… reporting the factors involved in or the rate of drug-resistant epilepsy (DRE) in adults with new-onset epilepsy (NOE). This prospective cohort study characterizes DRE and risk factors in a pure adult cohort with NOE or newly diagnosed epilepsy (NDE). There are very few studies reporting the …
-
Delineation of the genetic causes of complex epilepsies in South African pediatric patients
… Sub-Saharan Africa bears the highest burden of epilepsy worldwide. A proportion is presumed to be genetic, but this aetiology is buried under the burden of infections and perinatal insults, in a setting of limited awareness and few options for testing. Children with developmental and epileptic …
-
Anterior temporal lobectomy. A cross-sectional observational study of potential surgical candidates at a single institute
Background: Epilepsy is a common neurological disorder, associated with serious cognitive and psychosocial burdens, especially when poorly controlled. Mesial temporal lobe epilepsy (mTLE) is the most common form of human focal epilepsy. It is often refractory to antiepileptic drugs, and the most …
-
Advanced clinical MRI for better outcome in epilepsy surgery. Focusing on fMRI and prediction of verbal memory decline.
… of advanced MRI technology to improve results of epilepsy surgery, with focus on language and memory functions. Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been referred to high resolution 3T MRI with and without surface …