Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"drug-resistant bacteria"”.
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… and other ESKAPE pathogens (including carbapenem-resistant Acinetobacter baumannii). Interestingly, these analogues were resistant to enzymatic degradation in the presence of recently reported D-stereoselective peptidases. <br/><br/>Secondly, brevicidine represents a promising candidate for …
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Antibacterial activity of the crude extract and fractions of spirostachys africana against multi-drug resistant bacteria
… diseases, specifically those caused by multi-drug resistant bacteria in the last decade has made it a necessity to investigate a variety of antimicrobial drug sources, such as plants. Medicinal plants have played a significant role in drug discovery for western pharmaceuticals recently and …
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Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
… facilities (RCFs) act as reservoirs for multidrug-resistant organisms (MDRO). There are scarce data on colonisation with MDROs in Africa. We aimed to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods …
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Detection and characterization of antibiotic resistance plasmids in Cheney biosolids
… It has been shown that during sewage treatment, resistant bacteria are selected because of the presence of antibiotics and their byproducts. These resistant bacteria are more likely to transfer resistance genes to other bacteria. In the current study, we examined Cheney biosolids for the presence …
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Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a novel mode of action has become of critical importance to modern medicine. …
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Controlled release films and functional surfaces targeting infection, inflammation, and bleeding
… antibiotics has led to a worldwide increase in drug-resistant bacteria. As an alternative to these conventional treatments, local therapeutic delivery has the potential to effectively treat cellular dysfunction while avoiding drug toxicity. This thesis focuses on developing degradable …
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The production, design and application of antimicrobial peptides
With the spread of drug-resistant bacteria, existing antibiotics are losing their potency. Antimicrobial peptides (AmPs) represent an exciting class of drug candidates, particularly because their mechanism of action is unlikely to induce drug resistance. If resistance to AmPs were also slower to …
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Design, Synthesis, and Evaluation of Small Molecules in the Discovery of Novel Antimicrobial Agents
<p>The increasing prevalence of antibiotic-resistant bacteria, including Mycobacterium tuberculosis, Streptococcus pneumoniae, Staphylococcus aureus, and Enterococcus faecalis, pushes us to discover new antibacterial agents to maintain adequate patient coverage. This body of work highlights the use …
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Identification and functional evaluation of a bioactive peptide QUB-2669 from the skin secretion of the American bullfrog Lithobates catesbeiana
… antibiotic substitutes against the multi-drug resistant bacteria has become a global concern. Amphibian skin, secreting many bioactive peptides, is a rich source of novel antimicrobial peptides. In this thesis, QUB-2669, derived from the skin secretion of the American bullfrog, Lithobates …
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Total Synthesis of Mangrolide A
… were discovered. The emergence of multi-drug-resistant bacteria has jeopardized the human health. The total synthesis of the natural products plays a crucial part in modern organic chemistry. Mangrolide A was isolated from a rare marine actinomycete strain Actinoalloteichus spitensis by …
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Molecular cloning, peptide synthesis and bioactive assessment of a skin defensive peptide, QUB-2658 from the skin secretion of <i>Limnonectes fujianensis</i>
… were found to have excellent broad-spectrum antibacterial activities and inhibit drug-resistant bacteria, which made AMPs a potential new antibacterial drug source. Frog skin secretions are the most abundant source of AMPs and thus they have been widely studied by researchers. <br/><br/>In this …
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An Investigation of Antibiotic Residue in Non-Commercial Beef in Southwest Missouri
… health threat. A public health fear is that drug-resistant bacteria could develop that are resistant to all known antibiotics and the diseases they cause might be incurable. The CDC policy advises taking antibiotics only when absolutely necessary and only in the prescribed manner. Abuse …
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Development and Mechanism of Action of Antimicrobial Coatings
… pathogens, such as the most recent coronavirus, drug-resistant bacteria, or fungi. The antimicrobial coatings were composed of a variety of adhesives and active antimicrobial ingredients. Traditional adhesives and recently-invented adhesives were incorporated into the coatings, and active …
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Molecular cloning and bioactivity assessment of a bioactive peptide QUB-1509 from the skin secretion of the Asian frog Hylarana guentheri
… of antibiotics has resulted in the increase of drug-resistant bacteria and as numerous people have now died from super-bacterial infections worldwide, the quest for and development of novel antibiotics is urgent and significant. Temporins are among the smallest peptides that have been discovered …
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The discovery and functional study of a bioactive peptide, QUB-3000, from the defensive skin secretion of the northern leopard frog, Rana pipiens
To solve the drug-resistant microorganism problem, antimicrobial peptides (AMPs) have been studied as alternatives for traditional antibiotics. AMPs can inhibit and kill gram-negative bacteria, gram-positive bacteria, fungi and even cancer cells. Compared with traditional antibiotics, it is much …
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Novel collective prey evasion response of Pseudomonas aeruginosa PAO1 to soil micropredator Myxococcus xanthus DK1622
… is on the rise because of the threat of multi-drug resistant bacteria. Looking at the hunting strategy of soil-based bacterial micropredators is one avenue of exploration. Myxobacteria are soil predators with a wide prey range including Gram-negative and Gram-positive bacteria, fungi, and …
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Investigating the anti-inflammatory effects of plant derived compounds in tuberculosis using the THP-1 macrophage model
… effectively treated with the currently available drugs; however, poor adherence to therapy and the emergence of drug resistant bacteria has significantly impaired efforts to eradicate TB. Therefore, new therapies and therapeutic strategies are required to combat TB. One of the proposed new …
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Identification, molecular cloning and modification of skin-derived bioactive peptides from selected Hylidae and Ranidae
… different extents and are less prone to induce bacterial resistance. However, during the evaluation of therapeutic potential, the unfavorable factors of peptides were revealed like modest MIC values relative to conventional antibiotics, higher costs of synthesis/production, stability against …
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Medical Microbiology: Discovery of New Antimicrobial Drugs to Treat Clinically Relevant Antibiotic Resistant Pathogenic Bacteria
… impacts that may result from continued spread of drug resistant infections. These actions include discovery of new antibiotics and community engagement in AMR. Natural product screening methods are arguably the most efficient way to identify novel antibiotics, but can be frustrated by the repeated …
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Structural Studies of the Receiver Domain of LytR from Staphylococcus Aureus and Interaction Studies of TraW and TrbC from the F Plasmid of Escherichia Coli
The emergence of the multi-drug resistant bacteria and the evolutionary spread of the antibiotic resistance genes have become a great concern to human health. Bacteria use various systems in combination or alone in response to environmental stressors and stimuli to adapt to changing conditions. …
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