Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"drug-resistant TB"”.
-
The relationship between chest X-ray findings, bacterial load and treatment-related outcomes in persons with extensively drug resistant TB
Multi-drug resistant tuberculosis (MDR-TB) was first recognized in the 1990s with an increase in caseload of eighty-two percent between 2000 and 2007. Extensively drug-resistant tuberculosis (XDR-TB), a more difficult and more expensive form of TB to treat with poorer outcomes, emerged in South …
-
Outcomes of patients undergoing lung resection for drug-resistant TB and the prognostic significance of pre-operative positron emission tomography/computed tomography (PET/CT) in predicting treatment failure
Background: Even with newer and repurposed anti-TB drugs almost a third of patients with XDR-TB have unfavourable outcomes. In patients with localised disease and adequate pulmonary reserve, surgery is an important adjunctive treatment. However, there are no outcome data from TB endemic countries, …
-
Prevalence of drug-resistant tuberculosis and associated risk factors among patients in the Northern Region of South Africa
Background: Drug-resistant TB is a major global health threat, driving the ongoing TB epidemic and increasing morbidity and mortality worldwide. Currently, national tuberculosis (TB) control programmes are challenged by the emergence of drug resistance to more anti-TB drugs resulting in multi-drug …
-
Does the inclusion of the cost and burden of adverse drug reactions associated with drug-resistant TB treatment affect the incremental cost-effectiveness of new treatment regimens? A case study from the introduction of bedaquiline in South Africa National TB Programme
… Africa has one of the world’s highest burdens of TB, HIV/TB co-infection, and drug-resistant TB. Second-line TB treatment is less effective, more expensive, and more toxic than treatment for drug-sensitive TB. Nearly 1 in every 5 persons who starts treatment for drug-resistant TB in South Africa …
-
Efficacy and safety of novel and repurposed drugs for the treatment of drug-resistant tuberculosis
… There is widespread concern about the rise of drug-resistant TB because treatment outcomes of affected patients remain poor and treatment options are limited. After more than a forty-year gap without any breakthrough discovery, several new (bedaquiline and delamanid) and repurposed drugs …
-
Drug-drug interactions between antiretrovirals and bedaquiline
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. People living with HIV are particularly susceptible to TB infection, and treatment of HIV-TB co-infection is challenging for multiple reasons, including potential drug-interactions. Drug-resistant TB is difficult to treat …
-
Extensively drug-resistant tuberculosis in Africa: prevalence and factors associated: a systematic review and meta-analysis
… information regarding prevalence of extensively drugresistant tuberculosis (XDR-TB) in Africa. Although countries in Africa conduct national tuberculosis surveys on a regular basis, this information has not been systematically reviewed to ascertain the overall prevalence of XDR-TB in Africa. …
-
Synthesis, structure-activity relationship and solubility profiling of antimycobacterial aminoquinazolinones
Tuberculosis (TB) is a communicable disease caused by an infectious bacterial pathogen called Mycobacterium tuberculosis (Mtb), which is acquired through the inhalation of bacilli-containing droplets. With the emergence of resistant strains (multidrug-resistant TB (MDR-TB), extensively …
-
Synthesis, characterisation, structure-activity and structure-property relationship studies of quinazolinones as antimycobacterial agents
Mycobacterium tuberculosis (Mtb) is the pathogen responsible for Tuberculosis (TB), one of the most prolific killers among communicable diseases, second only to HIV/AIDS. The World Health Organisation (WHO) estimated 10.4 million people contracted TB in 2015, with 1.4 million fatalities recorded in …
-
Tuberculosis: standards and resources for quality improvement in resource limited settings
… about 2 million a year. The fight to eradicate TB is located primarily in countries that are resource poor and disproportionately affected by HIV and the development of drug resistant TB. The primary means with which to affect TB globally are to decrease transmission locally, mainly by effective …
-
Gastric resident systems for large dose drug delivery
… patient and the quality of the health care team, drug regimen complexity also affects treatment outcomes. For example, adherence decreases as the number of pills per dose and the number of doses per day increases. For diseases where potent medications are available, depot formulations provide …
-
Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), is one of the leading causes of death worldwide. The present short-course therapy is six months long for drug-susceptible M. tb strains, and up to two years for multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB …
-
Mathematical models for Tuberculosis spread in humans
… transmission dynamics of tuberculosis (TB) and discussed their implications to human health. The first model is analyzed in the presence of treatment of active TB persons and the screened asymptomatic TB infectives. The second model is analyzed by looking at treatment of drug sensitive …
-
Studies into Transcriptional Pausing Regulators and Drug Resistance in Mycobacterium Tuberculosis
<p>Tuberculosis (TB) is the leading cause of death worldwide due to an infectious agent. Although this is true globally, the greatest impact of TB is concentrated in regions of the world that are plagued by poverty and scarce resources. Mycobacterium tuberculosis (Mtb) is the bacterium that causes …
-
Three-Dimensional (3D) pharmacophore-based identification of possible ATP-synthase inhibitors for mycobacterium tuberculosis (Mtb)
Tuberculosis (TB) is defined as a chronic infectious disease caused by the air-borne transmission of Mycobacterium tuberculosis (Mtb). Due to high prevalence of Mtb in South Africa, it is classified as a high burden country by the World Health Organization (WHO). Multi-drug resistant TB (MDR-TB) …
-
Repositioning fusidic acid for tuberculosis: semi-synthesis of analogues and impact of mycobacterial biotransformation on antibiotic activity
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the leading causes of death globally, especially in low and middle-income countries. TB is primarily a curable disease, with chemotherapy predicated on a combination of four drugs. The increase in multiple forms of …
-
Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs.
… leads represents a significant challenge in drug discovery. This challenge is widely visible in neglected diseases such as tuberculosis, which is an infectious disease caused by bacillus Mycobacterium tuberculosis. The urgent need in search of new biological entities to fight back TB and drug …
-
Design of a large-dose minimally invasive drug delivery device for Tuberculosis
Tuberculosis (TB) affects millions of people all over the world, and in India has an incidence figure of about 2.8 million individuals annually. The TB treatment regime is quite involved, generally requiring six months and multiple medications. A lack of medication adherence can lead to …
-
Exploring barriers to TB contact tracing and screening: health service providers’ perspective
Tuberculosis (TB) continues to be a global public health challenge, with South Africa experiencing one of the highest TB incidence rates worldwide, exacerbated by its intertwined battle with and the emergence of drug-resistant TB strains. The study conducted in iBhayi Township, Eastern Cape …
-
Molecular epidemiology, susceptibility profiles, outcomes and transmission dynamics in patients with extensively drug-resistant tuberculosis (XDR-TB) in two provinces of South Africa
Background: Recent gains in TB control in South Africa are being reversed by drug-resistant tuberculosis (MDR-TB and XDR-TB), which has a high mortality, is a threat to health care workers, and is prohibitively costly to treat. MDR-TB has been supplanted by XDR-TB, resistance beyond XDR-TB, and …
Page 1 of 2