Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"drug-levels"”.
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Examining the distribution of ketamine and metabolites in decomposed skeletal tissues: development of a high throughput approach and application to an environmental and decomposition study
… using skeletal tissues as a biological matrix in drug analysis. The majority of these studies have been completed on a small scale so a larger scale is needed for further research. Here, a high throughput microwave assisted extraction (MAE) and microplate solid phase extraction (MPSPE) protocol is …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, rapamycin were entrapped in the core of polymeric micelles and solubilized. Polymeric …
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Development and application of novel analytical methods for molecularly targeted cancer therapeutics
A detailed understanding of correlations of drug levels with drug action is an important aspect of the pre-clinical, clinical development and routine use of anti-cancer drugs. In furtherance of this important aim, the research in this thesis sought to develop and apply novel, highly sensitive, …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Plasma concentrations of nelfinavir and viral suppression in HIV-1 infected pregnant women
… optimal viral suppression in pregnancy, drug toxicity and resistance development, NFV levels need to be evaluated in this population to guide dosing recommendations. METHODS: As part of a prospective cohort study maternal blood was collected at 18-28wks, 32-37wks and at delivery. Times of …
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The pharmacologenetics of lopinavir in a cohort of black African HIV/AIDS patients
… through the use of antiretroviral (ARV) therapy. Drugs used in ARV therapy target different major steps of the HIV reproductive cycle. These are nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs/NNRTIs); fusion/entry inhibitors; integrase inhibitors; and protease inhibitors …
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Therapeutic and virological outcomes in adults living with HIV / AID at 6 and 12 months after initiation of first-line highly active antiretroviral therapy in an urban population in Namibia
… evolution of viral resistance due to suboptimal drug levels. Studies have shown that drug adherence of at least 80% can result in viral load suppression. There is no literature on the association between the level of adherence to antiretroviral therapy and the degree of virological suppression in …
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Optimisation of analytical methods for monitoring monoclonal antibody therapy in Inflammatory Bowel Disease
… Infliximab and adalimumab. However, low drug levels and immunogenicity (development of anti-drug antibodies) are associated with treatment failure. Therapeutic drug monitoring, using drug and anti-drug antibody measurements improves treatment outcomes. This thesis aims to optimise and …
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Towards Rapid Measurement of Non-Nucleoside Reverse Transcriptase Inhibitors in a Portable, Low-Cost Platform
… viral loads and treatment failure. Providing drug-level feedback (DLF) can identify those with subtherapeutic ARV levels quickly to promote interventions to improve outcomes. Most DLF approaches measure drug levels via liquid chromatography-tandem mass spectrometry (LC-MS/MS), which can incur …
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Nose to Brain Delivery of Therapeutic Agents
… frequent administration. Brain targeting of drugs by intranasal route is a safe and noninvasive method of drug delivery which allows frequent administration and is certainly more patient compliant than the currently folloinvasive methods. In this study, the plausibility of delivering …
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Artemisinin-Based Combination Therapy (ACTs) Drug Resistance Trends in <em>Plasmodium falciparum</em> Isolates in Southeast Asia
… the parasite has developed resistance to many drugs created to treat and prevent the disease. Artemisinin and its derivatives are the new gold standard for treatment of malaria, yet treatment failures in clinical studies are starting to be reported. Clearly, artemisinin resistance needs to be …
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Development and application of novel approaches to quantitate therapeutic drugs in human blood
… in this work was the determination of both drugs simultaneously in one sample in a simple, rapid and cost effective assay. This was achieved using solid phase extraction and LC-UV analysis. The main challenge was developing a low cost assay to detect the drugs within a clinically relevant …
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Intranasal delivery of therapeutics targeted to CSF and Brain
… from the Brain/CSF. Therefore to prolong the drug levels in the target tissue fluids, thermosensitive in situ gels were developed using poloxamers. As the poloxamers are poorly cleared from the applied region particularly when multiple applications are executed subsequently, the use of …
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Tuberculosis In paediatric kidney transplant recipients a single centre experience
… dose was required to maintain therapeutic blood levels. Isoniazid prophylaxis was protective against development of tuberculosis (p=0.04). ) and was associated with fewer infections within the first year of transplantation although this was not statistically significant (p = 0.3). Gender, age and …
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Design and in vitro development of resorbable urologic drug delivery device
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous maintenance of plasma and tissue drug levels and the potential for reduced side …
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Die Bedeutung der Proteasehemmer-Plasmakonzentration für das Lipodystrophiesyndrom bei Patienten mit HIV-Infektion unter HAART
Durch die Entwicklung neuer antiretroviral wirksamer Therapieschemata konnte in den letzten Jahren die Letalität HIV-Positiver deutlich gesenkt werden. Zur Gruppe der Hochaktiven Antiretroviralen Therapie (HAART) gehören die Proteaseinhibitoren (PI) mit den Substanzen Ritonavir (RTV), Saquinavir …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
… to patients and that accurate measurement of drug levels during chemotherapy is proven to be more beneficial to patients, currently no chromatographic method exists for the measurement of any anthracycline and taxane drugs in a single assay. It would be useful to carry out therapeutic drug …
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Biochemical, Social and Psychiatric Aspects of Drug Overdoses
… have been made into the problem of deliberate drug overdoses, with the intention of setting up a permanent data base for collection of clinical and social information about patients admitted to the West Midlands Regional Poisoning Treatment Centre after drug overdose incidents. This involved …
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Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
… known about the effect of pregnancy on anti-TB drugs concentrations. A critical challenge to the global efforts to control the tuberculosis epidemic is the spreading of drug resistance to first-line tuberculosis drugs. The treatment of drug-resistant tuberculosis relies on both new …
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Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows
… in the livestock show industry often involves drug testing. Detection of therapeutic drugs at very low concentrations in approved animal species raises questions about current anti-doping regulations in exhibition animals. Therefore, the purpose of this research was to identify and address data …
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