Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"drug-based"”.
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Understanding the formation of American mental health policy preferences, 1952-1981
… States, the emergence of an outpatient-centered, drug-based model of mental health care was physically feasible from the 1950s onward, with the introduction of thorazine and other first-generation antipsychotics. However, it was not until 1981, with President Reagan’s veto of the Mental Health …
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A computational semantics system for detecting drug reactions and patient outcomes in personal health messages
… to medicine. A physician needs the outcomes of a drug, situationally relevant to a particular patient. We propose a system for patient outcomes utilizing computational semantics, which effectively digests message groups. Filtering identifies personal comments, by eliminating useless messages. …
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The Establishment and Regulation of Melanocyte Stem Cells in Zebrafish
… the first part of this thesis, I develop a drug based method of ablating melanocytes in the adult zebrafish body. The drug is a copper chelator, neocuproine: NCP) that I show causes death specifically of melanocytes in adult, which allows for regeneration from melanocyte stem cells: …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… Hence, there is an urgent need for new effective drug-based treatments.<br/>TAM (TYRO3, AXL and MERTK) family receptors are involved in tumour development, progression, metastasis and resistance to targeted therapies in several cancers. Our group previously showed overexpression and …
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
… would also alter β cell function. Using a drug-based approach, we examined function in islets treated with a BIRC-inhibitor (MV1; Smac-mimetic). Ex vivo, MV1-treated mouse islets showed impaired GSIS. In vivo, MV1 disrupted glucose homeostasis as MV1-treated islets failed to provide normal …
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Investigating transmembrane TNF and transmembrane p55TNFR mediated signaling in host immune function during Mycobacterium tuberculosis infection
… immune response was carried out using a 'drug-based' M. tuberculosis reactivation model. Here, mice that were challenged with a low dose of M. tuberculosis were exposed to INH-RIF treatment for six weeks in drinking water, after which therapy was withdrawn and immune responses during …
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Evaluation of Iohexol Clearance to Estimate Glomerular Filtration Rate in Normal Horse Foals
… septicemia, endotoxemia and nephrotoxic drug administration. Measurement of renal function is an important feature not only in the diagnosis, but also in the prognosis and management of renal disease. Commonly used drugs such as phenylbutazone and gentamicin can be highly nephrotoxic …
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Design of multidimensional microplasma array for biofilm removal and dynamic photonic crystals
… disinfect the system have proven unsuccessful. Based on understanding of the interaction between a microplasma jet array and drinking water simulated biofilm, the microplasma jet array integrated-otoscope has been conceived and realized as an alternative to antibiotic treatment. For the first …
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Using human induced pluripotent stem cells to model cystinosis
… failure before 10 years of age. Although, a drug-based therapy is available for cystinotic patients, the progression to kidney failure can only be delayed not prevented. A major challenge in the cystinosis field is the variation in cellular phenotypes between cell-based models of cystinosis …
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Actin Cable Function and Regulation in the Budding Yeast, Saccharomyces cerevisiae
… for actin dynamics. Second, I conducted a drug-based screen for novel regulators of actin cables (Chapter III). Previous studies revealed a role for the yeast formins (Bni1p and Bnr1p) in stimulating polymerization of F-actin for actin cable formation, elongation and retrograde flow, and …