Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"drug tolerance"”.
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A New Class of Antibiotic That Prevents Drug Tolerance, Persistence, and Resistance By Controlling Emergence of Phenotypes.
<p>The fight against bacterial infections and innovations in antibiotic therapy has never halted throughout human history. However, bacteria have evolved smartly and resistance against practically all conventional antibiotics has been developed. Furthermore, bacteria can form biofilms, which are …
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Drug induced tolerance mechanisms of the fungal pathogen Candida albicans
… of resistance. Here we describe mechanisms of drug tolerance.<p></p>
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Novel Inhibitors for Isocitrate Lyase as a Potent Antitubercular Agent for Mycobacterium Tuberculosis
… with latent TB. Current first- and second-line drugs used to treat TB require adherence to an extended period of therapy (at least six months) and do not target latent TB. It has been shown that the enzyme isocitrate lyase (ICL) is essential for the survival and persistence of Mtb in latent TB. …
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Quinolone mechanism of action: sensitivity, mutagenesis and tolerance
… But the improper and excessive use of these drugs over the last few decades has led to an alarming increase in antimicrobial resistance; coupled with the recent decrease in antibiotic discovery, it is widely thought that we are approaching a post-antibiotic era. A less well-understood problem …
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Examination of potential elicitors of operant and respondent behaviors in smokers
… that compensatory responses may play a role in drug tolerance and relapse. In one preliminary study assessing the role of compensatory responses to smoking stimuli (Machado, 2011), drops in carbon monoxide (CO) were observed only when smokers viewed smoking related stimuli. However, it is …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
… patients, some of these treatments can result in drug tolerance and may be linked to increased mortality. CpG oligodeoxynucleotides (ODNs) is a synthetic ligand that targets Toll-like Receptor (TLR) 9. It has been evaluated as a therapeutic agent for the treatment of cancer, infectious diseases, …
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Preclinical Modelling of Breast Cancer Drug Responses
… the DNA damage response are entering preclinical drug development. However, the success of new therapies is dependent upon preclinical models which mirror clinical drug responses and accurately capture the heterogeneity of this complex disease. Patient-derived tumour xenografts (PDTXs) have been …
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Combinatorial biochemistry of triterpene saponins in plants
… compounds, due to, among others, the growing drug tolerance and resistance in microorganisms and newly emerging diseases. In microorganisms, combinatorial biochemistry is a widely used tool to increase structural variation in several classes of (microbial) natural products. Despite the …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
… for cancers driven by fusion oncogenes, drug resistance remains a significant challenge, in part because we still lack a clear understanding of the broader implications of their activity for cell signaling and how these largely cytoplasmic proteins activate downstream pathways that …
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Targeting Lsr2/DNA Complexation for Dysregulation of Gene Expression in <i>Mycobacterium tuberculosis</i>
The identification of new drug targets and mechanisms of action against tuberculosis has become urgent, as the emergence of drug-resistant strains has made many treatments ineffective. Lsr2 is a protein encoded by the <i>Mycobacterium tuberculosis</i> genome that acts as a global repressor of …
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The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
… repair pathway choice that is associated with drug tolerance in glioblastoma.">1</a>]. </p> <p>Our previous study in melanoma demonstrated that the development of novel inhibitors targeting the redox regulation domain of APE/Ref-1 is a promising strategy for melanoma treatment. To date, limited …
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Design, synthesis and biological evaluation of verapamil analogues, reversed isoniazids and hybrid efflux pump inhibitors against Mycobacterium tuberculosis
… but has been hampered by the emergence of drug resistance in the causative bacterium, Mycobacterium tuberculosis (Mtb). Resistant strains of Mtb counter the efficacy of various anti-TB drugs via mechanisms that help it overcome the toxic and inhibitory effects of these drugs. These …
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… longer killed by currently used antitubercular drugs that target actively growing bacteria. The dormancy model of tolerance has been the center of antitubercular drug research with the pursuit of drugs to target bacterial determinants that are expressed in the nonreplicating phase of infection. …
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Causes of Naive Ethanol Avoidance in Drosophila Melanogaster
BACKGROUND: Alcohol dependence is a pressing public health concern, yet little is still known about its molecular causes. Although current studies have started to understand human addiction, Drosophila research is used as a tool to carry out more genetic and behavioral approaches that are crucial …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
Acquired drug tolerance has been a major challenge in cancer therapy. Recent evidence has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug tolerant mutants in cancer. The mechanisms associated with persister phenotypes are highly …
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
… TKI (GM-TKI), but is insufficient to predict drug tolerance, the ability of a cell line to sustain proliferation under drug. In drug combination experiments targeting co-mutated pathways, I show that some degree of tolerance to GM-TKI is explained by oncogenic co-mutations, but not across all …
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Nicotine Addiction and Impulsive Behaviour: Disentangling the Relationship
Drug addiction can now be considered a global epidemic with considerable psychological, physical, social and economicc osts. Substantial research remains focused upon furthering our understating of the disorder, for which current treatments are limited in their effectiveness. More recently there …
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The reduction of tolerance to the anticonvulsant effects of antiepileptic drugs
Tolerance has been shown to develop to the anticonvulsant effects of many different antiepileptic drugs. In some cases, tolerance to antiepileptic drug effects is so complete that the drugs become clinically ineffective, even at toxic doses. This is clearly problematic for the treatment of …
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Omics-driven and constraint-based modelling of microbial community metabolism
… samples, as well as evidence for higher drug tolerance in auxotrophs. In the second collaboration, I analysed data from sequenced soil isolates and metagenomes which were also screened in the lab for individual amino acid auxotrophies by colleagues. A metagenomics-driven metabolic …
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Population dynamics of bacterial persistence
… attack, by keeping a fraction of population in a drug tolerant state, the persister state. Specifically, persister cells grow more slowly than normal cells under growth conditions, but survive longer under stress conditions such as the antibiotic administrations. Bacterial persistence is …
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