Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 149 for “"drug therapy"”.
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Drug therapy - a challenge in primary care.
Introduction: Drug therapy in primary care is a broad field, with two areas previously identified as particularly challenging: treatment of the elderly and prescription of antibiotics against uncomplicated upper respiratory tract infections (URTIs). General practitioners’ (GPs’) attitudes and …
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Recent advances in drug therapy of tuberculosis
… resistance. These current anti-tuberculosis drugs , their side effects ,resistances and recent diagnosis methods are summarized in this thesis.
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Aspects on optimisation of drug therapy in the elderly
Introduction: Elderly patients often use many drugs, increasing the risk for drug-related problems. Aim: To optimise drug therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with …
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Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis
… Unfortunately, some types of epilepsy have drug resistance rates of up to 40%. Classically, targets for antiepileptic drugs have included glutamatergic ion channels. However, interfering with excitatory signalling at these channels can alter normal neural communication and can have negative …
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Dietary Methionine and Lysine Utilization by Chicks as Influenced by Coccidial Infection and Drug Therapy
… interactions between ionophorous anticoccidial drugs and dietary factors in both healthy and coccidial-infected chicks. The ionophores studied were monensin and narasin, and the dietary factors were L-lysine$\cdot$HCl, L-arginine, DL-methionine, protein level and source as well as dietary …
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Novel Micropatterned Substrate for Investigation of Ovarian Cancer Aggregate Formation and Response to Epigenetic Drug Therapy
… to better mimic in vivo response of tumors to drugs. This study will evaluate the feasibility of using a novel micropatterned substrate that enables 3D microenvironments for in vitro investigations of OvCa. The substrate was created through technologies used in integrated circuit fabrication …
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Oesophago-gastric cancer: factors influencing presentation and the effects of antisecretory drug therapy on symptoms and diagnosis
… in the diagnosis and the effect of antisecretory drug therapy (AST).
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Conception and Implementation of a Pharmacogenomic Plausibility Check: Integrating Molecular Data to Optimize Established Drug Therapy Safety Workflows
… availability of freely accessible information on drug-gene interactions enables the use of such data for a plausibility check during the prescribing process, thereby enhancing the safety of drug therapy. By conducting a pre-emptive test of the genotype of relevant enzymes, the result can be …
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Investigation of minor groove binders (MGB), non-ionic surfactant vesicles (NIV) delivery systems and IL-4i1 as novel pathogen- and host-directed drug therapy for tuberculosis
… with HIV and highest numbers of multi-drug resistant (MDR) and extremely resistant (XDR) TB per capita. The current treatment regimen is decades old and requires a prolonged period of 6 months. The lack of efficient TB therapy and the emergence of MDR and XDR TB, there is an urgent need …
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The Role of e-Antigen in Hepatitis B Infection
… absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, a particle produced by hepatitis B virus, in the pathogenesis of hepatitis B infection. To accomplish this goal, I will provide biological background as well as previous …
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A systematic approach to improving pharmacotherapy in the elderly
… and systematic approach on improving pharmacotherapy in the elderly (the LIMM-model) would lead to a more appropriate and accurate drug use in the elderly. The elderly use many drugs and are more prone to suffer from adverse drug reaction. It is therefore important to address the quality of …
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Modeling of HIV, SIR and SIS epidemics on time scales and oscillation theory
… continuous three dimensional linear model of drug therapy for HIV-1 decline on time scales in order to derive new discrete models that predict the total concentration of plasma virus as a function of time. We compare these models to explore the impact of the theory of time scales. After …
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Reservoir-based devices for the monitoring and treatment of disease
… despite significant investments in diagnostics, drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid tumors and their response to …
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A randomised controlled trial comparing two models of medication review in older patients in a community pharmacy setting
… outcome measures used, with 1.7 and 1.9 clinical drug therapy problems (cDTPs) identified at baseline and a cDTP resolution at follow up of 61% and 57% for the active and control groups respectively. There were no significant differences between the groups in the three secondary outcome measures …
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Establishing an evidence base for medicines use review: the development and evaluation of methodologies to assess the impact of medicines use review in practice
… The primary outcome measure was a reduction in drug therapy problems (DTPs) with a 64% resolution observed in the active group compared to only 3% in the control group over the six month period of the study. The effect size was significant (p<0.0001) with an absolute risk reduction of 61% and a …
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Design and in vitro development of resorbable urologic drug delivery device
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous maintenance of plasma and tissue drug levels and the potential for reduced side …
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The electrophysiological effects of Endothelin-1 in human atrial myocytes
… and diseases states or chronic pre-operative drug therapy. Spontaneous activity, defined as a depolarisation occurring during phase 3 of action potential repolarisation or a depolarisation of greater than 3 mV amplitude during phase 4, frequently interrupted action potential recordings during, …
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Interactions of sodium ethacrynate in intravenous admixture with selected cardiovascular and psychotherapeutic agents
<p>The possibility of drug incompatibilities is a matter of serious concern when administering two or more therapeutic agents. This is especially true in the case of parenteral administration when one must be aware not only of therapeutic interactions but also chemical and physical reactions that …
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Flexure-Based Device Enables Precise Quantitative Monitoring of Muscle Performance
… such as neuromuscular disease modeling and drug therapy testing. The contractile mechanisms of engineered muscle are often quantified by constraining the muscle on an elastomeric scaffold and measuring the scaffold’s deformation; however, structural imperfections in the scaffold can …
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Development of genotyping systems for pharmacogenomics profiling
Genetic variability in genes encoding drug metabolizing enzymes, transporters and targets are known to be the main factors of inter-individual differences in therapeutic outcome. Genetic factors are estimated to be responsible for about 15-30% of inter-individual variation in drug disposition and …
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