Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"drug therapeutics"”.
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In vivo identification of drug therapeutics for nemaline myopathy
… study employs the DiscoveryProbeTM FDA-approved drug library to perform a small molecule high-throughput drug screen as a strategy for developing therapies for Nemaline Myopathy (NM). Nemaline myopathy is a rare congenital neuromuscular disorder characterized by muscle weakness and the …
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… practice. However, the emergence of multidrug resistance (MDR), a mechanism that is not well understood, has, over time, eclipsed the progress that has been made in drug therapeutics. In this study we examined the effects of doxorubicin (DOX), cisplatin (CDDP) and one investigational TKI …
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… has not only marked a major milestone in cancer drug discovery but has also intensified efforts to directly target other KRAS mutations that have also successfully entered the clinic. However, treatment-associated resistance mechanisms have long threatened to attenuate clinical benefit through …