Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"drug targeting"”.
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Novel Implant Designs In Magnetic Drug Targeting
<p>The lack of drug selectivity to a specific site has been one of the major limitations in current therapeutic treatments. To overcome these limitations, many approaches have been proposed, one of which is magnetic drug targeting (MDT). The concept of MDT is to use drug carriers that contain a …
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Nanocarriers for drug targeting and improved bioavailability
… thesis debates, mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor …
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Staphylococcus aureus DNA gyrase: mechanism and drug targeting
… and improve the design of future antibacterial drug. This study has investigated features unique to S. aureus DNA gyrase: the potassium glutamate (KGlu) salt-dependent and salt-specific supercoiling. This KGlu dependency in S. aureus, but not E. coli gyrase, was partially attributed to the …
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Arzneistofftransport an der Blut-Hirn-Schranke: Drug Targeting mit liposomalen Konjugaten
… Entwicklung eines liposomalen Konjugats für ein drug targeting des Gehirns. Dazu wurde ein Zellkulturmodell der Blut-Hirn Schranke etabliert und ein liposomales Konjugat mit kationisiertem Albumin hergestellt. Kapillar-Endothelzellen wurden aus Schweinehirn isoliert und in Kulturgefäßen als …
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The expression and drug targeting of parasitic hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
We have expressed and purified human, two forms of P. falciparum, and Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HPRT) in E. coli using the pET expression system. The cDNA encoding the ORF of HPRT was amplified by PCR and transformed into E. coli cells using standard methods. …
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Cloning, expression, purification and drug targeting of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT)
The research concerns sub-cloning the gene for HGXPRT from Plasmodium falciparum from a vector with a His-tag facility to one without, expression of the protein in E. coli, and purification. On an analytical scale (40 ml culture), a purification procedure was developed that involves extraction of …
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Exploring cancer metabolism through isotopic tracing and metabolic flux analysis
… and rewired cellular metabolism. In addition, drug targeting of rewired metabolic pathways has been demonstrated to be a promising cancer treatment strategy. Despite this progress, a fundamental question remains unanswered: whether there is a difference in the metabolism of cancerous, fast …
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Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy
… the relationship between the function of the drug and the structure of its target, with the aim of discovering novel therapeutics that target nucleic acid secondary structures, selectively. The structure of the expanded DNA and RNA repeats that cause myotonic dystrophy type 1 (DM1) present a …
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Poly(ethyl glyoxylate) Solid-Core Particles for Drug Delivery
… stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger the release of cargo. Polymeric nanotechnology containing “self-immolative …
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Synthesis and Characterization of Thermally Responsive Nanocapsules Surface Decorated With Folic Acid For Targeted Drug Delivery and Cancer Destruction
… the outcomes of cancer treatment by facilitating drug targeting, tumor imaging, and treatment enhancements. Previously, we have synthesized and characterized Pluronic F127-chitosan nanocapsules for encapsulation and temperature controlled release of small molecules which could be useful for …
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Investigations Into the Function of Elp3 in Toxoplasma Gondii
… in parasite biology that could be useful in drug targeting. The goals of this thesis were to determine the function of TgElp3 and how the protein traffics to the OMM. In other species, Elp3 mediates lysine acetylation of histones and alphatubulin, and its radical S-adenosyl methionine (rSAM) …
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Investigating the interaction of a metallosupra molecular cylinder with nucleic acids
… the background of nucleic acid structures and drug targeting to nucleic acids. The concept of molecular recognition between drugs and nucleic acids is also discussed. Besides, being a drug target, DNA can be used as material for constructing beautiful architectures. Examples of these DNA …
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Stepwise Reconstitution of RNA Cellular Activity
… viral RNAs and apply them to viral RNA-targeted drug development. I first quantitatively examined the relationships among levels of reconstitution of the human immunodeficiency virus 1 (HIV-1) cellular process of transactivation. This process involves complex RNA-protein interactions between an …
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Syntheses and Bioactivities of Targeted and Conformationally Restrained Taxol Analogs
… since become one of the most important current drugs for the treatment of several cancers, including breast and ovarian cancers. Like almost all anticancer drugs taxol does have some toxic side effects and many tumors also show significant resistance to therapy with taxol. Drug targeting studies …
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Elucidating The Igfbp2 Signaling Pathway In Glioma Development and Progression
… progression, providing strong evidence that targeting the key players could potentially produce a significant benefit for human glioma patients. The elucidation of this signaling pathway is a critical step, since efforts to create a small molecule drug targeting IGFBP2 have so far not been …
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Xenophagy in response to gram-positive staphylococcus aureus and gram-negative salmonella enterica sv. typhimurium
… ULK1 represents an excellent candidate for drug targeting to control autophagy under various settings.This study aimed to investigate the role of autophagy in defence against two disease causing bacteria that are known for their ability to damage cells: Salmonella entericasv. Typhimurium and …
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Antimicrobial Producing Bacteria as Agents of Microbial Population Dynamics
… with the increasing pace of emergence of drug resistant pathogens (MRSA, XDR-TB, etc.). Modification of existing antibiotics with the additions of side chains or other chemical groups and genomics based drug targeting have been the preferred method of drug development at the corporate …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
… both brain and systemic responses. Antidiabetic drugs such as metformin and drug targeting Glucagon-Like Peptide-1 (GLP-1) are being proposed for psychiatric and cognitive treatments, although their use for non-diabetic purposes remains debated. Methods: The role of antidiabetic drugs in …
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The Design of Stable, Well-Defined Polymer-Magnetite Nanoparticle Systems for Biomedical Applications
… use as a treatment for retinal detachment, for drug targeting and delivery, and for use as a MRI contrast agent. This work outlines a general methodology to design well-defined, stable polymer-magnetite complexes. Colloidal modeling was developed and validated to describe polymer brush extension …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… liver failure. There are currently no approved drugs on the market for treating NASH leaving a major unmet medical need for drug discovery research. The aim of this dissertation is to better understand the pathophysiology of NASH and elucidate disease driving molecular mechanisms that can be …
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