Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"drug target identification"”.
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Computational analysis of biochemical networks for drug target identification and therapeutic intervention design
Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear that a holistic network approach is needed to identify drug targets that are …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
… in the NF-[kappa]B pathway that if inhibited/ targeted by added drugs normalize the levels of NF-[kappa]Bn. Also, since there is a limit to how effective single drug targets are in complicated diseases, identification of combinations of targets is very important. Existing experimental and …
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Computational modeling of knowledge and uncertainty in systems biology for drug target identification and protein engineering
… involved in immune response, to find promising drug targets for treatment of sepsis. I compared a sampling method to a worst-case search method for quantifying the uncertainty in responses to hypothetical inhibitors and found that the choice of method significantly impacts the results. I …
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Development and Application of Large-Scale Protein Folding Stability Analysis in Drug Target Identification and Disease Biomarker Discovery
… protein folding stability approaches in drug target identification and disease biomarker discovery. One goal of this work is to develop a novel chemo-selection strategy to improve the bottom-up proteomics readout in proteome-wide limited proteolysis experiments. Another goal of this work …
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Exploring the network’s world: From omics-driven machine learning workflow for drug target identification to quantification of signaling model diversity.
The drug discovery process is challenging, time-consuming, and costly, with drug target identification being an essential step in developing effective therapies. Drug repurposing offers a strategy for identifying new uses for existing drugs, aiming to simplify the process. Machine learning models …
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Approaches to Study Small Molecule Inhibitors and Their Targets
… for understanding cell biology or as clinical drugs, the small molecule's mechanism of action must be characterized. However, identifying a small molecule's target and characterizing its interaction with that target remain major challenges in the chemical biology field. In this thesis, I …
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New Methodology for Measuring Semantic Functional Similarity Based on Bidirectional Integration
… domain, this thesis introduces similarity-based drug target identification and disease networks using BSM scores. Application of BSM score is freely available through http://www.ittc.ku.edu/chenlab/goal/
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Understanding the role of CD4+ T cells in common immune-mediated diseases
… of nearby genes in T cells. Nonetheless, the target genes of most immune disease loci have yet to be discovered. In this dissertation, I describe three studies designed to further our understanding of the relationship between genetic variation, CD4+ T cell function, and disease risk. I first …
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery
… burden to global public health. Antimalarial drugs are a mainstay in efforts to control and eventually eradicate this disease. However, increasing drug resistance threatens to reverse recent gains in malaria control, making the discovery of new antimalarials critical. Antimalarial discovery is …
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The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Infectious Pathogens: Towards Host-Oriented Broad-Spectrum Drug
… of pathogens to adapt and develop resistance to drugs, and (ii) a shortage in the development and discovery of new anti-infective drugs. Host-Oriented Broad-Spectrum (HOBS) treatments have the promising potential to alleviate these problems. The HOBS treatment paradigm focuses on finding drug …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
… promising hit compounds, but elucidating the targets of these compounds, often a necessary step in the hit-to-lead development process, has been slow. This is because target identification has rested primarily on one technique, *in vitro* evolution and whole genome sequencing (IVIEWGA), which …
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Biases and Blind-Spots In Genome-Wide Crispr-Cas9 Knockout Screens
… candidate cancer-specific therapeutic targets. While it is widely accepted that CRISPR screening is both more specific and more sensitive than previously established methods, the limitations of this technology have not been systematically investigated.</p> <p>In this dissertation, …