Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"drug susceptibility"”.
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Single-cell mass measurements for drug susceptibility testing in cancer
Measuring the size distributions of micron-scale particles is of central importance in the biological sciences and for a wide range of industrial processes. The suspended microchannel resonator (SMR) is a sensor that measures the mass of individual micron-scale particles by detecting a shift in …
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A multiplex platform based on cellular barcoding for measuring single cell drug susceptibility
Predicting individual patient response to cancer drugs has been challenging. As many anticancer drugs aim to modulate cell deaths or growth inhibition, a useful assay for drug susceptibility would require direct assessment of phenotypic changes to cells upon drug treatment, such as cell viability …
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Riboswitch regulation of methionine metabolism and vitamin B12 uptake in mycobacteria – implications for drug susceptibility and pathogenesis
… essential for bacillary replication in vitro. Drug susceptibility testing to investigate the link between cobamides and the intrinsic resistance to anti-folate antibiotics confirmed novel mycobacterial vulnerabilities in cobamide-related methionine metabolism, indicating that the outcomes of …
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Investigation of the Genetic Basis of Antibiotic Resistance in Mycobacterium tuberculosis
… with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which …
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Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
… with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which …
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Detection of mixed Mycobacterium tuberculosis infections in South African TB Patients
… in single disease episodes, often with differing drug susceptibilities. This has important implications on drug susceptibility testing and the treatment of patients. It has also highlighted the relative contributions of exogenous reinfection and endogenous reactivation in TB disease progression. …
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Tuberculosis in Children: Diagnosis and Epidemiology
… the diagnostic role of microscopic observation drug susceptibility (MODS) and mycobacterial blood culture for diagnosis of TB in children as well as to present the epidemiological characteristics of paediatric TB in northern Vietnam with regard to drug resistance and genotypes of Mycobacterium …
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Weak signal identification and inference in penalized model selection
… The method is illustrated for HIV antiretroviral drug susceptibility data to identify genetic mutations associated with HIV drug resistance. We also provide signal's inference method based on the exact distribution of penalized estimator. The finite sample distribution is quite different from its …
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Measuring mass changes in single suspended and adherent cells, with applications to personalized medicine in Glioblastoma Multiforme (GBM)
… functional marker for the effects of anti-cancer drugs. In this thesis we adapt mass accumulation measurements for use in Glioblastoma Multiforme (GBM) patient-derived cell lines, exploring the heterogeneity between and within patient tumors, and validating the measurement as a predictor of drug …
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
… transmitting malaria. Due to decreased drug susceptibility of mature gametocytes, more investigation of the biology and metabolic requirements of malaria parasites during gametocytogenesis, as well as during the mosquito stages, are urgently needed to reveal novel targets for development …
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Repetitive Sequences Drive Rapid Adaptation in Candida albicans
… (LOH) confer increased virulence and antifungal drug resistance, yet the mechanisms and dynamics that drive these types of genome plasticity are not completely understood. In this dissertation, we build on foundational studies that identified recurrent, adaptive CNVs that occurred during …
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Molecular epidemiology, susceptibility profiles, outcomes and transmission dynamics in patients with extensively drug-resistant tuberculosis (XDR-TB) in two provinces of South Africa
… TB control in South Africa are being reversed by drug-resistant tuberculosis (MDR-TB and XDR-TB), which has a high mortality, is a threat to health care workers, and is prohibitively costly to treat. MDR-TB has been supplanted by XDR-TB, resistance beyond XDR-TB, and programmatically incurable TB. …
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Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance
… treated with a single dose of Metronidazole. Drug resistance is not common, but it is on the rise. In addition to increasing rates of drug resistance, Trichomoniasis also poses a public health threat as it has been shown to increase the risk of HIV transmission. In order to combat this …
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Rifampicin-resistant Mycobacterium tuberculosis: an emerging threat to human health in Botswana
… no variants resistant to new and repurposed drugs were detected in this study. In conclusion, this work demonstrates that RR-TB burden in Botswana is driven by genetically diverse Mtb strains and sustained by ongoing transmission. The detection of variants with mutations outside the …
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Accelerating antimalarial drug discovery through repositioning
… measures have been hampered by the emergence of drug resistance to most antimalarial therapies. Early signs of drug resistance to the current frontline option, the artemisinins, make it imperative that novel drug candidates are discovered. One possible short-term solution is drug repositioning, …
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Microbiological, genomic and transcriptomic analyses of human tuberculosis lung cavities
… unclear. METHODOLOGY: Multi- and extensively drug-resistant TB (MDR- and XDR-TB) patients scheduled for therapeutic lung resection surgery in Cape Town were prospectively recruited. Biopsies were obtained from specific positions in and around cavities. Drug-susceptibility testing, strain-type …
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Rifampicin-resistant tuberculosis in Botswana: barriers and risk factors influencing patient outcomes, case detection, and linkage to effective care and treatment
… associated with mortality, access to culture and drug susceptibility testing (DST) for patients at risk of RR-TB, access to first- and second-line DST among RR-TB patients, time to RRTB treatment, and patient and provider experiences with RR-TB management. Methods: Retrospective data (multiple …
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Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
… capsule size, salt tolerance, and antifungal drug susceptibility in C. deneoformans. For several QTL, I was able to identify candidate causal variants that underlie these loci. Two major effect QTL for amphotericin B resistance map to SSK1 and SSK2; regulators of the high osmolarity glycerol …
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Molecular Characterisation Of Clostridium Perfringens Isolates From Patients At Groote Schuur Hospital
… infections, as only identification and drug susceptibility testing are done in routine laboratories. The main aim of this study was to characterise 19 clinical isolates of C. perfringens (collected between 2017- 2020) using phenotypical and molecular methods such as PCR-based toxin …
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