Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"drug self-administration"”.
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SEX DIFFERENCES IN THE ROLE OF PKMζ IN DRUG SELF-ADMINISTRATION AND PREFRONTAL CORTEX SYNAPTIC PLASTICITY
… the trafficking of AMPA receptors (AMPARs), in drug taking behaviors and synaptic plasticity. PKMζ belongs to the protein kinase C family and is exclusively in the central nervous system. PKMζ is persistently active, making it an interesting target for persistent changes in the brain, such as …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… the goal of improving the knowledge base of how drugs of abuse function to create addicts and using currently uninvestigated areas of this knowledge base, we focused our research studies the male albino rat, and strived to explain how cocaine sensitization alters particular molecular mechanisms …
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The differential effects of stressors on aversive, novel and appetitive stimuli in rats
… Two studies examined the effect of restraint on drug self-administration. Restraint did not influence the acquisition or maintenance of cocaine self-administration, although restraint potentiated cocaine-induced locomotion. Restraint increased ethanol intake on the first post-restraint test only …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… and discrete cues previously associated with drug-taking (cue reactivity). Human drug users experience an increase in craving elicited by drug-paired cues over time, and in rodent models, a time-dependent increase in cue reactivity (‘incubation”) is observed during forced abstinence from drug …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… and discrete cues previously associated with drug-taking (cue reactivity). Human drug users experience an increase in craving elicited by drug-paired cues over time, and in rodent models, a time-dependent increase in cue reactivity (‘incubation”) is observed during forced abstinence from drug …
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Characterization of the synergistic effects of cocaine with lateral hypothalamic brain stimulation reward
… reward as would be predicted from the drug self-administration and conditioned place-preference literature. In Experiment 3, the widely held notion that tolerance to the rewarding effects of cocaine contributes significantly to the cocaine habit was tested in the brain stimulation …
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The Effects of Dopamine D3 Receptor Compounds on Oxycodone Self-Administration and Reinstatement in Female Cynomolgus Monkeys
… novel compounds. Studying nonhuman primates in drug self-administration is most predictive of the clinical condition in humans, thus, provides important clinically translational insight into medications development for treatment of substance abuse. Most drugs of abuse alter dopamine (DA) …
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Effetto nell’auto-somministrazione dell’agonista sintetico del recettore cannabinoide CB1, WIN 55,212-2, nel modello animale di depressione della bulbectomia olfattoria (OBX)
… bulbectomy model of depression with intravenous drug self-administration procedure to verify whether depressive-like rats display higher voluntary intake of the cannabinoid CB1 receptor agonist WIN 55,212-2 (WIN, 12.5 μg/kg/infusion). The olfactory-bulbectomized rat is a well-established model …