Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"drug seeking"”.
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… use disorder, is characterised by compulsive drug-seeking and intake in the face of mounting adverse and negative consequences. Despite the prevalence of illicit drug use within society only a small subset of individuals lose control over their intake after protracted drug use. Several …
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Withdrawal from Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities to Behavioral Deficits and Neurochemical Perpetuators of Neurotoxicity and Drug Seeking Behavior
… and health effects of MA use. Women begin drug use at an earlier age, escalate drug use quicker, have increased MA rates, and increased relapse rates compared to men<sup>7-14</sup>. Chronic MA use produces long term impairments in cognitive function ranging from memory deficits, executive …
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HIGH TRAIT MOTOR IMPULSIVITY IS AN ANTECEDENT TO COCAINE-SEEKING BUT NOT OXYCODONE-SEEKING BEHAVIOR IN RODENTS
… (e.g. impulsivity) and exposure to environmental drug-associated cues along with complex neurobiology as precipitating factors. Impulsivity is expressed in different forms (e.g. motor impulsivity, impulsive choice) and is associated with both cocaine use disorder and opioid use disorder. Animal …
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Behavioral Models of Cocaine Use Disorder
… into two broad categories of dysregulated drug taking and dysregulated drug seeking. However, distinguishing the drug seeking or drug taking components in self-administration models can be difficult since the consumptive and appetitive responses are both directed towards the same operant. A …
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Age- and sex-specific effects of amphetamines on cognition and serotonin in the orbitofrontal cortex
… opiates, respectively, for most abused illicit drug and highest prevalence of addiction. Epidemiological data reveal that adolescent and female drug users are at higher risk to develop addiction and have worse treatment outcomes than adults or males. Drug-induced cognitive deficits and …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… accumbens (NAc), consequently facilitating drugseeking behavior. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in cocaine addiction and demonstrated to increase neuronal excitability, therefore, the aim of the present study was to investigate the effect of intra-mPFC mGluR5 …
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The Role of Adult Neurogenesis in Cocaine Addiction
… of SGZ neural progenitors is decreased by drugs of abuse, yet it is not clear how the type and amount of drug as well as the pattern of administration changes long-term effects on neurogenesis. In addition, it is unclear what role if any SGZ neurogenesis plays in initiating drug-taking or …
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Evaluation of Glutamatergic Treatment in Reducing Nicotine Seeking Behavior in Rats
… (Nacc) as vital in the reinstatement of drug-seeking behavior. Restoring basal concentrations of extracellular GLU, thereby increasing tonic activation of the presynaptic group II metabotropic GLU receptors (mGluR2/3) by a single injection of N- acetylcysteine (N-AC) prevented …
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Effects of Norharmane and Nicotine on the Conditioned Place Preference of Mice
… produce place preference, indicating drug seeking behavior of the rewarding properties of each compound. Finally, a combination of nicotine and norharmane were administered together, and the same parameters were observed. A significant place preference for either drug alone, nor in …
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Neural Plasticity in the Amygdala Across the Development of an Incentive Cocaine Seeking Habit
Drug seeking behaviour is substantially influenced by drug-paired conditioned stimuli (CSs). The unexpected presentation of these Pavlovian CSs does not only immediately grab attention, but it also generates arousal and motivational states manifested as approach behaviour, and invigoration of …
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A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking
… availability are known to reinstate reward-seeking behaviors after periods of suppressed responding for a reward. Previous research indicates that the nucleus accumbens (NAcc) is a critical brain region involved in the relapse to drug-seeking behaviors and may likewise be involved in dietary …
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Synthesis and Evaluation of the Aristotelia Alkaloids at the α3β4 Nicotinic Acetylcholine Receptor
… promising. Antagonists for the α3β4 nAChR reduce drug-seeking behavior and withdrawal symptoms in rodent models, but a lack of selective ligands has limited further study. The solution may be found in the natural product aristoquinoline (ARQ), which is both moderately selective and potent at the …
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Sex differences in synaptic plasticity within the reward system: the role of PKMζ and implications for opioid use disorder
… substance use disorder, women escalate their drug consumption faster, exhibit higher craving during withdrawal, and have poorer treatment outcomes. Furthermore, as our cultural expectations of men and women have changed, there has been an increase in drug use in women and this increase is …
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Leptin Action on Dopamine Neurons: Biochemical and Behavioral Analysis
… regions commonly activated by hedonic foods and drugs of abuse, and therefore, potentially common mechanisms underlying behaviors associated with them. Additionally, the metabolic state of an animal can affect drug seeking behavior. The discovery that leptin receptor (Lepr) is expressed on …
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CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… disorder, best characterized by profound drug-induced neuroadaptations which drive drug-seeking phenotypes and persist in the absence of drug. In this dissertation we will examine circular RNA (circRNA) dysregulation following a rodent model of heroin self-administration and characterize a …
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Taurine's effect on cocaine reward and neurogenesis in the adolescent male rat brain.
… vulnerable to development of mental illness and drug-seeking behavior. According to the United Nations Office on Drugs and Crime, the psychostimulant cocaine is the second most popular illicit drug in the world. Cocaine, amongst having many detrimental effects, has shown to also decrease …
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Study of the Role of the Bed Nucleus of the Stria Termialis D1- and D2-Like Dopamine Receptors in Cocaine Self-Administering Rats
… of the stria terminalis (BST) in modulating drug seeking behaviors. With heavy reciprocal projections from the BST to various dopamine rich areas (ventral tegmental area (VTA), nucleus accumbens shell (NAc shell), retrorubral nucleus (RR), periaqueductal gray region (PAG)), BST dopamine …
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The Effect of Variability in Substance Abuse and Dependence Terminology on Physicians' Prescribing Decisions
Prescription drug abuse is a continuing problem in the United States. Educating physicians on issues related to prescription drug abuse is a key factor in preventing and treating this problem. High variability has been found in substance abuse terminology in the literature, textbooks, and …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… the goal of improving the knowledge base of how drugs of abuse function to create addicts and using currently uninvestigated areas of this knowledge base, we focused our research studies the male albino rat, and strived to explain how cocaine sensitization alters particular molecular mechanisms …
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