Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 704 for “"drug resistance"”.
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Functional Interrogation Of Anti-Cancer Drug Resistance
… to resist upfront target inhibition (intrinsic resistance) as well as, in cases where tumors are initially sensitive, develop resistance over the course of drug treatment (acquired resistance). The literature to date reveals a problem as complex as the tumor itself; the heterogeneity of cancer …
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A simulation model of antimalarial drug resistance
… stop as the change in response to antimalarial drug treatment requires the development of new drugs and innovation in the use of old drugs. This thesis focused on building a model of the spread of resistance to Sulfadoxine/Pyrimethamine (SP) in a setting where both SP and SP in artemisinin-based …
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Pharmacological modulation and manipulation of cancer drug resistance
… pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate specific forms of drug resistance. Sixty one novel compounds were tested in …
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CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY
… reporting the factors involved in or the rate of drug-resistant epilepsy (DRE) in adults with new-onset epilepsy (NOE). This prospective cohort study characterizes DRE and risk factors in a pure adult cohort with NOE or newly diagnosed epilepsy (NDE). There are very few studies reporting the …
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Folate transport and drug resistance in the African Trypanosome
… the knowledge of the mechanism of action and resistance of antifolate drugs in African trypanosomes with a specific focus on transport mechanisms. A media deficient in folate and thymidine was established which enabled the assessment of their modulation on antifolate in vitro potencies and …
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Determining patterns of cancer drug resistance from autopsy patients
Determining patterns of drug resistance is fundamentally required for improving clinical outcome of cancer treatment. The ability to study multiple samples from different metastatic sites of the same patient is a clinically and analytically challenging task, which has become possible with the …
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Language Models Predict Drug Resistance from Complex Sequence Variation
… to the development of vaccines, antiviral drugs, and antibiotics. Recently, neural language models trained on viral protein sequence evolution have shown promise in their ability to predict viral escape mutations, potentially enabling more intelligent therapeutic design [6]. Hie et al.’s …
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Exploiting fitness trade-offs to prevent antifungal drug resistance
The evolution of drug resistance in pathogenic microorganisms is typically viewed as an inevitable consequence of the selective pressures imposed by antimicrobial agents. However, although certain drugs rapidly lose efficacy in the clinic, others remain refractory to resistance. In my thesis, I …
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APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… with particular reference to the development of resistance. In recent years, the molecular chaperone Hsp90 has emerged as leading example of such a target-specific therapy. Heat-shock proteins are found at increased levels in many solid tumors and haematological malignancies. Their expression may …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… The most significant mechanisms of azole resistance include alterations or overexpression of the target enzyme, and overexpression of at least three distinct efflux pumps. Recently, azole-resistant vaginal C. albicans isolates have been detected in patients with recurring and refractory …
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Antibiotic Drug Discovery with an Eye Towards Overcoming Drug Resistance
… our everyday lives. The widespread emergence of resistance to currently used antibiotics is commonly attributed to an over use in our society. Such resistance, coupled with a lack of innovation and production of novel antibiotic drugs, threatens to return humanity to an era similar to one before …
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A Chemical-Genetic Map of Drug Resistance in Mycobacterium Tuberculosis
… can acquire an additional level of antibiotic resistance through specific chromosomal mutations. A better understanding of intrinsic and acquired drug resistance in Mtb is essential to develop faster treatments and better drug resistance diagnostics. We sought to understand the genetic basis …
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Analysis of prognostic and drug resistance markers in lung cancer
… of patients with lung cancer is chemotherapy resistance. In patients with NSCLC (80% of cases) initial response rates to cisplatin-based chemotherapy are modest at best. In the case of SCLC (20% of cases) the initial response rates to cisplatin-based chemotherapy are high. However relapse, …
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Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies
… precision oncology and therapeutics, cancer drug resistance, both primary and secondary, has greatly limited the potential of targeted therapies to improve patients’ lives. Here, we systematically define combination treatment strategies by using unbiased pharmacological and functional genetic …
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Leucyl-tRNA synthetase: dynamic subcellular relocalization and drug resistance mechanism
"The family of aminoacyl-tRNA synthetases (aaRS) are essential to all living cells. They are fundamental to setting the genetic code during protein synthesis by charging tRNA with a specific amino acid. As such, they have been selected by the pharmaceutical industries as optimal targets. A new …
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Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
Antimalarial drug resistance is a major factor affecting global malaria control, causing treatment failure and significant morbidity and mortality. Resistance has historically emerged in low-transmission areas before spreading to high-transmission areas, and there is consequently widespread …
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Investigation of the intrinsic mechanism of drug resistance in multiple myeloma
… whereby myeloma cells develop intrinsic resistance with a focus on resistance in the context of bortezomib treatment. The aims of this thesis were to examine multidrug resistance pumps as a mechanism of resistance in MM, to investigate the contribution of p53 signalling perturbations in …
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